细胞核仁形成区活性与反复自发流产相关性的探讨  

Relationship Between the Activity or Nucleolar Organizer Regions and Recurrent Spontaneous Abortion

作　　者：张志芬[1] 孙素芬 赵东云 姜淼 韩维田 肖淑香 王占平[5] 

机构地区：[1]沈阳医学院多功能实验室,沈阳110031 [2]生物化学教研室 [3]辽中县妇幼保健所 [4]辽宁省计划生育科学研究院实验研究中心,沈阳110031 [5]沈阳市第一人民医院,沈阳110041

出　　处：《沈阳医学院学报》2000年第4期203-205,214,共4页Journal of Shenyang Medical College

摘　　要：目的　探讨细胞核仁形成区活性与反复自发流产的关系。方法应用银梁ＮＯＲ技术，对反复自发流产患者夫妇和有正常生育史夫妇各３０对的中期染色体核仁形成区银染点（Ａｇ－ＮＯＲ）和近端着丝粒染色体银染联合（Ａｇ－ＡＡ）数进行对比分析。结果反复自发流产夫妇 Ａｇ－ＮＯＲ数量和女性Ａｇ－ＡＡ次数分别为６．７２，６．３９和０．３７，明显高于对照组的６．０７，５．８６和０．３１，二者间有显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。结论细胞核仁形成区活性增高是引起反复自发流产的重要因素。Objective To observe the relationship between the activity of nucleolar organizer regions (NOR) and the spontaneous abortion. Methods The Ag-NOR and Ag-AA numbers of the metaphase chromosomes in 30 couple with recurrent spontaneous abortion and 30 normal couple were analysed contrastively by the silver staining technique.Results The Ag-NOR numbers in cells of the couple with spontaneous abortion and the Ag -AA in cells of the women from the couple were 6. 72, 6. 39 and 0. 37, respectively. And those of control group were 6. 07, 5. 86 and 0. 31, The statistically significant differences were revealed between: them (P <0. 01, P <0.05). Conclusion The activity of nucleolar organizer regions increasing is one of the important factors causing spontaneous abortion.

关 键 词：核仁形成区 自发性流产 染色体 相关性 

分 类 号：R714.21[医药卫生—妇产科学]