内质网应激在肺纤维化发生中的作用  

Role of endoplasmic reticulum in pulmonary fibrosis

作　　者：顾盼[1] 方霞[1] 易祥华[1] 

机构地区：[1]同济大学附属同济医院病理科,上海200065

出　　处：《国际呼吸杂志》2013年第24期1896-1899,共4页International Journal of Respiration

基　　金：基金项目：上海市科学技术委员会科研基金资助项目（034119868）;上海市科学技术委员会医学重点科研基金资助项目（09411951600）

摘　　要：内质网是真核生物细胞内蛋白加工和合成等生命活动的重要场所。因此内质网内环境的稳定对于整个细胞内环境的稳定起着至关重要的作用。多种原因通过破坏蛋白质的正确折叠和细胞内Ca2＋的平衡导致内质网应激的发生，这与许多疾病的发生发展有密切联系。最新研究表明，肺组织内某些错误折叠或未折叠的蛋白沉积于内质网或某些病毒感染等原因引起细胞内质网应激的发生，导致肺泡上皮细胞大量凋亡、间质细胞增殖，最终导致肺纤维化。本文对内质网应激在肺纤维化发生中的作用及其机制的最新研究进展作一综述。The endoplasmic reticulum （ER） is an organelle of cells in eukaryotic organisms,which is involved in synthesis of proteins. The inner stability of ER plays an important role in maintaining the stability of intracellular environment. Many factors cause the occurrence of ER stress, which affects the occurrence and development of some diseases by preventing protein folding and destroying the equilibrium of calcium inside the cell. According to the latest researches, the accumulation of misfolded or unfolded proteins in ER and viral infections can lead to ER stress, which induces apoptosis of alveolar epithelial cells, proliferation of pulmonary interstitial cells, and eventually causes pulmonary fibrosis. This review focuses on the role and mechanisms of ER stress in the pathogenesis of pulmonary fibrosis.

关 键 词：内质网应激 未折叠蛋白反应 肺纤维化 

分 类 号：R563[医药卫生—呼吸系统]