气相色谱法测定缝合针线中2-氯乙醇残留量  

GC Detection of Ethylene Chlorohydrin in Surgical Suture

作　　者：尹庆和[1] 谭周飞 肖俏霞 李海燕[1] 王衍洪[1] 

机构地区：[1]广东东莞东华医院,东莞523110 [2]东莞市国药质量检测中心

出　　处：《中国药事》2013年第12期1294-1297,共4页Chinese Pharmaceutical Affairs

摘　　要：目的建立测定缝合针线中2-氯乙醇残留量的气相色谱法。方法依照国际标准ISO10993-7的气相色谱法,采用FFAP石英弹性毛细管柱（30m×0.32mm×0.25μm）,进样口温度200℃,检测器温度250℃,柱箱温度110℃。进样量1μL,分流比3,柱流速1.5mL·min-1。结果该方法灵敏准确,2-氯乙醇检测限为10μg,在52.75~422μg范围内保持良好的线性关系,缝合针线中2-氯乙醇平均回收率为98.8%。结论该方法可以作为缝合针线中2-氯乙醇残留量的测定方法。Objective To establish a method for detection of ethylene chlorohydrin in surgical suture by gas chromatography.Methods The ethylene chlorohydrin was determined by ISO10993-7 with gas chromatography.The FFAP quartz elastic capillary column（30m ×0.32mm ×0.25μm）was used with the inlet temperature at 200 ℃,the detector temperature at 250 ℃ and the oven temperature at 110℃. The sampling volume was 1μL,the split ratio 3,the column flow 1.5mL·min-1.Results The method was proved to be accurate and reliable.The minimum limit of ethylene chlorohydrin was 10μg,and the calibration curve had good linearity in range between 52.75-422μg.The average rate of recovery of ethylene chlorohydrin was 98.8%.Conclusion The method is suitable for the determination of ethylene chlorohydrin in surgical suture.

关 键 词：2-氯乙醇 残留量 气相色谱 缝合针线 检测方法 环氧乙烷 

分 类 号：R197.39[医药卫生—卫生事业管理] R991[医药卫生—公共卫生与预防医学]