强力宁与甘利欣对心内直视手术患者血清心肌酶及心脏复苏的影响  

Effect of potenline,diammonii glycyrrhizinatis on serum myocardial enzmes and resuscitation of heart in patients undergoing open heart surgery

作　　者：刘流[1] 陈启智[1] 谢才姣[1] 周建美[1] 常业恬[1] 李李[1] 吕志平[1] 

机构地区：[1]湖南医科大学附属第二医院麻醉科教研室,长沙市410011

出　　处：《临床麻醉学杂志》2001年第1期7-9,共3页Journal of Clinical Anesthesiology

摘　　要：目的　研究强力宁、甘利欣对心内直视手术心肌缺血再灌注损伤的保护作用。方法　48例室间隔缺损需行心内直视手术患者分为四组 ,每组 12例。强力宁组、甘利欣组在麻醉诱导后分别用 10 %葡萄糖 10 0ml加入强力宁 2 5mg/kg或甘利欣 2 5mg/kg静滴 ;对照组 ,未阻断组只用 10 %葡萄糖 10 0ml静滴。在转流开始时、开放主动脉 30分钟、4、12、2 4小时从桡动脉取血测心肌酶浓度 ,并记录心脏复跳的方式、心律失常和需用升压药维持的例数。结果　开放主动脉后 4、12、2 4小时强力宁组、甘利欣组、未阻断组血清心肌酶浓度明显低于对照组 ,心脏电击复跳、心律失常、需用升压药维持的例数亦明显少于对照组 ;开放主动脉后甘利欣组心肌酶浓度、电击复跳、心律失常、用升压药维持的例数与未阻断组相近 ,但明显低于 /少于强力宁组。结论　强力宁、甘利欣对心内直视手术心肌缺血再灌注损伤有明显保护作用 。Objective To study the protective effect of potenline and diammonii glycyhizinatis on myocardiac ischemia reperfusion injury in patients undergoing open heart surgery.Methods Forty eight patients with VSD scheduled for elective open heart surgery were divided into potenline group(Ⅰ),diammonii glycyrrhizinatis group(Ⅱ),control group (Ⅲ) and nonoccluding aorta group (Ⅳ).Following anesthesia induction,2 5mg/kg potenline in group Ⅰ or 2 5mg/kg diammonii glycyrrhizinatis in group Ⅱ was given intravenously.The arterial blood samples were taken to measure the concentration of serum enzymes at the beginning of CPB, 30min,4,12,24h after release of the aortic cross clamp.Results After release of the aortic cross clamp,the concentration of serum enzymes in group Ⅰ,Ⅱ and Ⅳ was significantly lower than that in group Ⅲ.The incidence of patients with arrhythmia was lower than that in group Ⅲ.Conclusion Potenline and diammonii glycyrrhizinatis have protective effects on myocardiac ischemia reperfusion injury and diammonii glycyrrhizinatis is better than potenline.

关 键 词：强力宁 甘利欣 再灌注损伤 心肌保护 

分 类 号：R654.2[医药卫生—外科学]