意外抗体对ABO血型鉴定的干扰  

Interference of unexpected antibodies in ABO blood group identification

作　　者：李敏芳[1] 曹奎杰[1] 胡丽华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院输血科,武汉430022

出　　处：《临床血液学杂志（输血与检验）》2013年第6期848-849,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:分析意外抗体在ABO血型鉴定中的干扰作用,为ABO疑难血型鉴定提供思路和对策。方法:对全自动血型仪检测的ABO血型正反定不合的样本结合盐水试管法、抗体筛查及鉴定结果以及病史资料综合分析。结果:26例引起正反定不合的抗体中IgM 18例,IgG 8例,分别是抗-M 10例、抗-Lea 2例、抗-N 1例、抗-P1 2例、抗-JKa 1例、抗-D 2例、抗-E 2例、抗-C 1例、抗-c 1例、抗-Fya 1例、自身抗体3例。结论:IgM和IgG两类意外抗体均能引起ABO血型正反定不合,反定细胞应该选用常见意外抗体对应抗原表位缺失的红细胞。Objective：To analyze the interference of unexpected antibodies in ABO blood group identification and give some ideas to solve the problem. Method：Combined the conventional tube test, antibody screening and i- dentification and patients clinic history records to analyze ABO discrepancy results detected by automatic blood group analyzer. Result：Among these 26 discrepancy results of ABO blood group,there were 10 cases with anti-M, 2 anti Lea, 2 anti P1,2 anti-D and 2 anti-E respectively, 1 case with anti-N, anti-JKa, anti-C,anti-c and anti-Fya re- spectively,and other 3 cases were cold autoantibodies. Conclusion： Unexpected antibodies of IgM and IgO could both cause discrepancy of ABO blood group and red blood cells selected to determine reverse blood group should lack corresponding epitopes.

关 键 词：意外抗体 ABO血型鉴定 

分 类 号：R457.1[医药卫生—治疗学]