解酒护肝饮对酒精性肝损伤大鼠血清和肝组织TNF的影响  

The effect of relieving alcoholism & protecting liver drink on the blood serum,liver tissue TNF of alcoholic liver injury rat

作　　者：杨牧祥[1] 田元祥[1] 姚树坤[2] 朱孝轩[3] 李荣彦 李莉[5] 曹刚[1] 徐慧明[1] 马全庆[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]河北医科大学第四临床医学院 [3]邯郸医学高等专科学校 [4]新乐市中医院 [5]河北省人民医院

出　　处：《中国全科医学》2001年第1期27-29,共3页Chinese General Practice

基　　金：河北省卫生厅资助项目!(No .990 2 5 )

摘　　要：目的　通过观察解酒护肝饮对酒精性肝损伤大鼠血清和肝组织TNF的影响 ,验证其对酒精性肝损伤的防治作用及药效。方法　以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,分别预防给药和治疗给药后检测各组大鼠血清和肝组织TNF含量。结果　预防给药结果表明 :模型大鼠血清及肝组织TNF较正常组均明显升高 ,均具有显著性差异 (均P <0 0 1) ;预防给药各组血清及肝组织TNF均低于模型组 ,均具有显著性差异 (均P <0 0 1) ,但各治疗组间未见明显统计学差异 (P >0 0 5 ) ,治疗给药结果与预防给药结果一致。结论　解酒护肝饮能够通过降低血清和肝内TNF含量 。Objective To observe the effect of relieving alcoholism & protecting liver drink on alcoholic liver injury of rat's blood serum,liver tissue TNF as well as test its pharmacological effect and function mechanism.Methods The rat model of alcoholic liver injury was duplicated by filling the stomach with white spirit and then was given prevention medicine and treatment medicine respectively,and the rat's blood serum,liver tissue TNF in each group were determined,and Yiganling as well as decoction of pueravia flower were used as comparison.Results The result of prevention medicine suggested that the amount of TNF in rat's blood serum and liver tissue of model group was increased,compared with that of normal group,there was significant difference statistically(P<0 01).The amount of TNF in rat's blood serum and liver tissue of each prevention treatment group was reduced,compared with that of model group,there was significant difference statistically(P<0 05).And there was not significant difference statistically in each treatment group(P>0 05).There was consistent between the result of treatment medicine and that of prevention medicine.Conclusion The drink of relieving alcoholism & protecting liver could prevent alcoholic liver injury by effectively reducing the amount of TNF in blood serum and liver.

关 键 词：酒精性肝损伤 解酒护肝饮 大鼠 预防 TNF 中医药治疗 

分 类 号：R259.75[医药卫生—中西医结合]