2型糖尿病尿5种蛋白联合检测的临床意义  

Clinical significance of combined measurements of urinary five proteins in type 2 diabetic patients

作　　者：叶山东[1] 李素梅[1] 陈燕[1] 杨静[1] 汤涛[1] 

机构地区：[1]安徽省立医院内分泌科,合肥23001

出　　处：《安徽医学》2001年第1期6-8,共3页Anhui Medical Journal

基　　金：安徽省卫生厅科研基金资助课题! (A95 - 1 998- 0 9)

摘　　要：目的 :了解 2型糖尿病尿 5种蛋白变化的临床意义。方法 :对 2 0 4例 2型糖尿病患者和 44例正常对照者(C组 )同时进行 2 4h尿Alb、Trf、IgG、RBP、NAG(分别简称UAE、UTE、UIE、URBPE及UNAGE)、尿糖排泄 (UGE)和肌酐清除率 (Ccr)的检测。根据 2 4hUAE分为 3组 :正常白蛋白尿组 (Ⅰ组 ) ;微量白蛋白尿组 (Ⅱ组 )及大量白蛋白尿组(Ⅲ组 )。结果 :(1) 2 0 4例中 ,微量和大量白蛋白尿发生率为 41 2 %和 7 8% ,与C组相比 ,Ⅱ组Ccr略降低 (P >0 0 5 ) ,Ⅲ组Ccr明显降低 (P <0 0 5 ) ;(2 )UTE在 3组患者中均与UAE呈显著相关 ;UIE在Ⅲ组与UAE明显相关 ;UNAGE在Ⅱ组与UAE明显相关 ;(3)URBPE增高的发生率在Ⅰ组、Ⅱ组和Ⅲ组分别为 11 5 %、42 9%和 75 %。结论Objectiv:To assess the clinical significance of urinary five proteins change in type 2 diabetics.Methods:24 hour urinary albumin、transferrin、IgG、retinol-bingding protein,N-acetyl-glucosaminidase,glucose excretion (named UAE,UTE,UIE,URBPE,UNAGE and UGE) and creatinine clerance rate (Ccr) were measured and analysed in 204 type 2 diabetic patients and 44 control subjects (group C). 204 patients were divided into three groups according their 24h UAE:Group Ⅰ (normoalbuminuria),group Ⅱ (microalbuminuria) and group Ⅲ (macroalbuminuria).Results:(1) The prevalence rates of micro-and macroalbuminuria were 41.7% and 7.8% among 204 patients.Compared with group C,the Ccr decreased sligtly in group Ⅱ (P>0.05),but decreased significantly in group Ⅲ (P<0 05);(2) UTE (in all three groups),UIE(in group Ⅲ) and UNAGE (in group Ⅱ) had significant positive relationship with UAE;(3) The raised prevalence rates of URBPE were 11.5%、42.5% and 75.0%,respectively among group Ⅰ,group Ⅱ and group Ⅲ.Conclusion:Urinary five proteins combination measurement had more importmant value for the early diagnosis and localization of diabetic kidney disease.

关 键 词：糖尿病肾病 尿微量蛋白 早期诊断 Ⅱ型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]