2480 WIZARD2珈玛计数器测量正电子核素^(68)Ga的应用研究  

Application Study to Determination of ^(68)Ga Radioactivity by a 2480 WIZARD2 γ Counter

作　　者：徐希杰[1] 邹美芬[1] 陈全成[1] 潘栋辉[2] 徐宇平[2] 陈飞[2] 

机构地区：[1]江苏省原子医学研究所研究部仪器室,江苏无锡214063 [2]江苏省原子医学研究所分子影像中心

出　　处：《中国辐射卫生》2013年第6期651-653,共3页Chinese Journal of Radiological Health

基　　金：中国博士后科学基金(2013M531389);江苏省卫生厅项目(H201028);江苏省自然基金(BK2011166)

摘　　要：目的建立2480 WIZARD2珈玛计数器测定68Ga放射性活度的方法。方法制备68Ga贮备液(3.7×107Bq/mL)。倍比稀释后,用PE公司2480 WIZARD2珈玛计数器测定活度,建立标准曲线,对测量时间、精密度、重复性、稳定性及测量效率等进行研究。结果 2480 WIZARD2珈玛计数器的测量时间优选为5 s。68Ga活度在18.5~3.7×104Bq范围内线性关系良好,回归方程为:y(cpm)=24.67x(Bq),r=0.9999。最低检测限为3.7 Bq,计数器本底值为(142±49)cpm。精密度、重复性与稳定性试验的RSD分别为0.86%,0.70%和0.71%。珈玛计数器的测量效率为(41.04±0.95)%。结论该法操作简单、快速、准确且灵敏,适用于68Ga的放射性活度测定。Objective To establish a method for determination of 68Ga radioactivity via a 2480 WIZARD2 γ counter. Methods A68Ga stock solution（ 3. 7 × 107Bq / mL） was prepared. After dilution,the radioactivity was determined by the counter. The standard curve,measurement time,precision,repeatability,stability and efficiency were studied. Results The measurement time is suitable at 5 seconds. There was a good linearity between 18. 5 Bq ~ 3. 7 × 104Bq of 68Ga radioactivity and the regression equation was y（ cpm） = 24. 67x（ Bq）,（ r = 0. 9999）. The lowest detectable limit was 3. 7Bq. The value of background was（ 142 ± 49） cpm. The RSD of precision,repeatability and stability testing RSD were 0. 86%,0. 70% and 0. 71%,respectively,and the efficiency was（ 41. 04 ± 0. 95） %. Conclusion The method is simple,rapid,accurate and sensitive. It is suitable for determination of low dose68Ga radioactivity.

关 键 词：珈玛计数器 正电子核素 镓 测量 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]