活血化瘀药对CCL_4所致小鼠急性肝损伤的保护作用  

Protective effect of blood-activiating and stasis-dissolving drugs on the acute liver injury in mice caused by CCL_4

作　　者：黄林邦[1] 韩光[1] 饶俐俐[1] 熊桂生[2] 

机构地区：[1]赣南医学院病理生理学教研室 [2]赣南医学院病理学教研室

出　　处：《赣南医学院学报》1991年第1期8-11,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：用25％CCL-4复制小鼠急性肝损伤,分别给小鼠复方丹参(A组,n=10)、川芎嗪(B组,n=9)和生理盐水 (C组,n=9)预处理3d。与C组比较,A组的肝受损程度较轻(P<0.05),肝坏死灶的平均直径较小(P<0.01);B组则无显著性差异(P>0.05),血清及肝组织匀浆中的MDA,红细胞内SOD的含量,三组间差异无显著性意义。提示复方丹参对急性肝损伤有一定的保护作用(川芎嗪则无),其保护机理与减轻体内脂质过氧化反应无关。The models of liver injury in mice were reconstructed with 25%CCL4.The mice were divided into three groups,which were pretreated respectively with Inj.Salviae Miltiorrhizae Co. (A group, n =10),Inj. Ligustrazini phophatis(B group,n = 9)and Saline(C group, n = 9)for three days.The degree of liver injury and the average diameter of necrotic foci on liver slicers presented a striking contrast between A and C group(P<0.05)and didn't between B and C group(.P> 0.05).The level of SOD in RBC and MDA in seara and homogenate of liver didn't appear notable differences(P>0.05)anong the three groups.It is illustrated that Inj.Salviae Miltiorrhizae Co.should have a certain protective effect on acute liver injury and the mechanism of the protective effect is not related to the decrement of lipid peroxidation in vivo.

关 键 词：活血化瘀药 肝损伤 CCL4 

分 类 号：R285.5[医药卫生—中药学]