神经母细胞瘤引起骨破坏机制的研究进展  

Research progress of the mechanism in bone destruction caused by neuroblastoma

作　　者：郝腾(综述)[1] 马晓莉(审校)[1] 

机构地区：[1]首都医科大学附属北京儿童医院血液中心,100045

出　　处：《国际儿科学杂志》2013年第6期555-557,共3页International Journal of Pediatrics

摘　　要：神经母细胞瘤是极易发生骨转移的儿童实体肿瘤,其发生骨转移后引起影像学可见的溶骨性破坏.在这个过程中,神经母细胞瘤细胞、成骨细胞和骨基质细胞通过分泌一系列相关因子促进骨转移发生.该文对引起神经母细胞瘤骨转移破坏机制的研究进展作一综述.Neuroblastoma is one of the solid tumors in children which easily metastasizes to bone.It causes radiographic appearance of osteoclastic reactions after bone metastases.In the process,neuroblastoma cells,osteoblasts and bone stromal cells secrete a series of related factors to promote bone metastases.In this paper,the progress of the mechanism in bone destruction caused by neuroblastoma is reviewed.

关 键 词：神经母细胞瘤 骨破坏 细胞因子 

分 类 号：R114[医药卫生—卫生毒理学]