肠道微生态和新生儿坏死性小肠结肠炎  

Intestinal microbiota and neonatal necrotizing enterocolitis

作　　者：李美雪(综述)[1] 周伟(审校)[1] 夏慧敏(审校)[1] 

机构地区：[1]广州医科大学附属广州市妇女儿童医疗中心新生儿科,510120

出　　处：《国际儿科学杂志》2013年第6期575-578,共4页International Journal of Pediatrics

摘　　要：肠道微生态是由体内有益菌及有害菌共同构成的生态环境,是人体最大、最复杂的微生态系统.研究表明,适当的肠道微生物定植过程有助于肠道结构和功能发育以及免疫系统成熟,它决定了之后肠道发生疾病的风险.肠道微生态或益生菌与新生儿坏死性小肠结肠炎（neonatal necrotizing enterocolitis,NEC）的关系已越来越受到关注.该文就新生儿肠道微生态的构成及作用、肠道微生态在NEC发生中的作用及机制、益生菌对NEC的防治作用等研究进展作一综述.The intestinal microbiota is composed of beneficial bacteria and harmful bacteria in the body as the ecological environment,which is the largest,most complex microecosystem.There is emerging evidence that appropriate colonization process of intestinal microbes contributes to development of intestinal structure and function and maturation of immune system,which determines the risk of intestinal diseases.More and more studies focus on the relationship between intestinal microecology or probiotics and neonatal necrotizing enterocolitis （NEC）.This article reviews the composition and function of neonatal intestinal microbiota,the intestinal microflora in the pathogenesis and mechanism of NEC and preventive effects of probiotics on NEC.

关 键 词：坏死性小肠结肠炎 微生态 益生菌 新生儿 

分 类 号：R722.1[医药卫生—儿科]