模具成型法构建多分支壳聚糖导管  

A multi- branch chitosan conduits fabricated by molding method

作　　者：陈丽洁[1] 钟伟[1] 龚锴[2] 何成朝 胡敏[3] 

机构地区：[1]济南军区青岛第一疗养院,山东青岛266071 [2]清华大学,北京100084 [3]301医院,北京100853

出　　处：《实用医药杂志》2013年第11期1004-1006,共3页Practical Journal of Medicine & Pharmacy

基　　金：国家自然科学基金资助项目(项目编号:30872898);全军后勤科研十二五重点课题"现代战创伤中枢神经损伤康复体系的构建与应用研究"(课题编号:BWS11J003)

摘　　要：目的制作可用于面神经趋向性再生研究的多分支壳聚糖导管。方法根据兔面神经设计并制作多分支导管模具,改进模具成型法的制作工艺,得到多分支壳聚糖导管,检测导管的溶胀系数及微观结构。结果制成的多分支壳聚糖导管外形光滑,各分支的长轴在同一平面内,管道通畅,溶胀系数为368±13.2。结论模具成型法可以根据实验需要构建出复杂形状的壳聚糖导管,所制导管可用于面神经趋向性再生研究。Objective To fabricate a multi - branch chitosan conduit for the study of facial nerve tropism regeneration. Methods A mold was designed and produced according to the facial nerve of the rabbits. A multi - branch chitosan conduit was fabricated by the improved process based on the molding method. Then the swelling index and microstructure of the con- duit was evaluated. Results The shape of the multi - branch chitosan conduit was smooth, and the long axis of all the bran- ches was at the same plane. All the branches were unobstructed. The swelling index of the chitosan conduit was 368 ± 13.2. Conclusion Multiple shaped chitosan conduits can be fabricated by the molding method according to the experimental need. The conduit fabricated in this study is an optional choice to the study of the facial nerve tropism regeneration.

关 键 词：多分支导管 壳聚糖 面神经 神经再生 

分 类 号：Q819[生物学—生物工程]