PTEN、EGFR和GH在子宫内膜异位症和异位恶变内膜中的表达及意义  

Expression and Significance of PTEN,EGFR and GH in Endometriosis and Ectopic Malignant Change Endometrium

作　　者：王成鑫[1,2] 周红艳[1,2] 黄萱[1,2] 刘丽江[1,2] 

机构地区：[1]江大病理诊断所 [2]江汉大学医学院病理与病理生理学教研室,湖北武汉430056

出　　处：《江汉大学学报（自然科学版）》2013年第5期81-85,共5页Journal of Jianghan University：Natural Science Edition

摘　　要：目的:研究PTEN、EGFR(epidermal growth factor receptor)和GH(human growth hormone)在子宫内膜异位症(endometriosis,EMs)和异位恶变内膜中的表达及意义,探讨EMs恶变机理及特点。方法:应用免疫组织化学方法,检查PTEN、人表皮生长因子受体(EGFR)及生长激素(GH)在子宫内膜异位症在位、异位及异位恶变内膜组织中的表达。结果:PTEN在24例在位、异位和异位恶变内膜中的阳性率分别为66.67%(16/24)、37.50%(9/24)和20.00%(1/5),异位和异位恶变内膜中的阳性率远低于在位内膜,差异有统计学意义(P<0.05),而异位、异位恶变内膜间的阳性率差别不大,说明两者的生物学特点相似;GH在在位、异位和异位恶变内膜的阳性率分别为87.18%(102/117)、85.38%(111/130)和80.00%(4/5);EGFR在在位、异位和异位恶变内膜中的阳性率分别为54.70%(64/117)、89.23%(116/130)和80.00%(4/5),异位和异位恶变内膜的阳性率均高于在位内膜。GH、EGFR在异位和异位恶变内膜中的阳性率接近。因此,提出不典型EMs(atypical endometriosis,aEM)和EMs恶性变的诊断标准。结论:子宫内膜异位症拥有肿瘤组织的局部浸润、远处转移等生物学特点,容易恶变。GH、EGFR和PTEN在子宫内膜异位症的发生、发展及恶变过程中起重要作用。PTEN表达水平的下降和缺失,同时伴有EGFR、GH的高表达可被视为内异症恶性转化的重要标志。Objective： To study the expression and significance of PTEN, EGFR （epidermal growth factor receptor） and GH （human growth hormone） in endometriosis （EMs）, malignant trans- formed endometrium of EMs and investigate the malignant mechanisms and the characteristics of EMs. Methods ： Immunohistochemical S-P method was used to examine the expressions of PTEN, EGFR and GH in the eutopic, ectopic and ectopic malignant transformed endometrium of EMs. Results ： The positive rate of PTEN in eutopic, ectopic and ectopic malignant transformed endometri- um of EMs of 24 cases were 66.67% （ 16/24）, 37.50% （9/24） and 20.00% （1/5） respectively, the positive rate in ectopic and ectopic malignant transformed endometrium of EMs was lower than that of eutopic endometrium and there was statistical difference （P 〈 0. 05） , nevertheless the positive rate between ectopic and ectopic malignant transformed endometrium of EMs had no statistical differ- ence （P 〉 0. 05） which indicated that the biologic characteristic of the two lesions were similar; The positive rate of GH in eutopie, ectopic and ectopic malignant transformed endometrium of EMs were 87. 18% （ 102/117）, 85.38% （111/130） and 80.00% （4/5） respectively; The positive rate of EGFR in eutopic, ectopic and ectopic malignant transformed endometrium of EMs were 54.70% （64/117）, 89.23% （116/130） and 80.00% （4/5） respectively, the positive rate in ectopic and ectopic malig- nant transformed endometrium of EMs were higher than that of eutopic endometrium. The positive rate of EGFR and GH in ectopic and ectopic malignant transformed endometrium of EMs were simi- lar. Therefore suggested the diagnostic criteria of aEM （atypical endometriosis） and malignant change of EMs. Conclusion ： Endometriosis possesses some features of neoplasm such as adhesion, invasion, metastasis and can transform to malignant tumor. GH, EGFR and PTEN play important role in occurrence, development and malignant transformation of EMs. Especial

关 键 词：子宫内膜异位症 生长激素 表皮生长因子受体 PTEN 恶性变 

分 类 号：Q579.13[生物学—生物化学]