小儿金宁口服液抗菌抗病毒实验研究  

Experimental Study on Antibacterial and Antiviral Actions of Xiao'er Jinning Oral Liquid

作　　者：时艳[1] 许惠琴[2,3] 俞晶华[4] 

机构地区：[1]江苏联合职业技术学院连云港中医药分院,江苏连云港222007 [2]南京中医药大学药学院,江苏南京210023 [3]江苏省中药药效与安全性评价重点实验室,江苏南京210023 [4]南京中医药大学第一临床医学院,江苏南京210023

出　　处：《南京中医药大学学报》2013年第6期538-543,共6页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省“青蓝工程”科技创新团队支持计划;中医儿科重点学科资助项目(EZK2009019)

摘　　要：目的观察小儿金宁口服液体内外抗菌和抗病毒作用。方法采用试管法测定小儿金宁口服液在体外对12种临床常见致病菌的影响;采用金黄色葡萄球菌、肺炎双球菌致小鼠腹腔感染模型观察其体内抗菌作用;采用甲型、乙型流感病毒致细胞病变法观察其体外抗病毒作用;采用流感病毒、仙台病毒致小鼠呼吸道感染模型观察其体内抗病毒作用。结果小儿金宁口服液对所试9种细菌、甲型、乙型流感病毒均有不同程度的抑制作用,其中对金黄色葡萄球菌、甲型流感病毒的抑制作用较强。小儿金宁口服液能不同程度地减少金黄色葡萄球菌、流感和仙台病毒感染小鼠的死亡率,延长其存活时间,降低病毒感染小鼠的肺指数,减轻肺病变程度。结论小儿金宁口服液具有一定的抗菌抗病毒作用。OBJECTIVE To observe effect of Xiao＇er Jinning Oral Liquid on bacterium and virus in vivo and vitro.METHODS The antibacterial effect in vitro of Xiao＇er Jinning Oral Liquid on common 12 kinds of pathogenic bacteria in clinic was observed through test tube methods while antibacterial affected in vivo by infecting mice with Staphylococcus aureus and Streptococcus pneumoniae.The antiviral effect in vitro was observed through cytopenic method induced by influenza A and influenza B while antiviral effect in vivo through mouse models with respiratory infection by influenza virus and Sendai virus.RESULTS Xiao＇er Jinning Oral Liquid had an inhibitory effect on the 9 kinds of bacteria,influenza A,influenza B in different degrees,especially more for Staphylococcus aureus and influenza A,reduced mortality rates of mice infected by Staphylococcus aureus,influenza virus and Sendai virus with varying degrees,prolonged the survival time,decreased lung index of infected mice and diminished pulmonary pathological lesion.CONCLUSION Xiao＇er Jinning Oral Liquid has some antibacterial and antiviral effect.

关 键 词：小儿金宁口服液 抗菌 抗病毒 

分 类 号：R285.5[医药卫生—中药学]