正交试验优选联苯肼酯γ-环糊精的包合工艺  

Optimization of γ-Cyclodextrin Inclusion Technology for Bifenzate by Orthogonal Test

作　　者：王佳[1] 马超[1] 于驰[1] 陈维韬[1] 吴学民[1] 

机构地区：[1]中国农业大学理学院,北京100193

出　　处：《现代农药》2013年第6期15-16,39,共3页MODERN AGROCHEMICALS

基　　金：国家"十二.五"科技支撑计划(2011BAE06A06-10)

摘　　要：研究γ-环糊精包合联苯肼酯的制备工艺。以γ-环糊精与联苯肼酯的物质的量之比、包合时间、包合温度为考察因素,以包合物收率和联苯肼酯包合率的综合评分为评价指标,采用正交试验优选工艺,确定最佳包合工艺条件为n(γ-环糊精)∶n(联苯肼酯)=1∶1,搅拌时间为5 h,包合温度为30℃。该工艺联苯肼酯包合率及包合物收率较高,包合效果良好。The optimum inclusion process conditions for bifenzate using γ-cyclodextrin were studied.The inclusion technology was optimized by orthogonal test with the mole ratio of γ-cyclodextrin to bifenzate,inclusion time,inclusion temperature as factors and with the yield and the inclusion rate as indexes for evaluation.The optimum inclusion conditions were established as the follow： n（γ-cyclodextrin）∶n（bifenazate）=1∶1,the inclusion temperature at 30℃ for5 h.The technology was effective with high yield and inclusion rate.

关 键 词：联苯肼酯 Γ-环糊精 包合物 正交试验 

分 类 号：TQ461[化学工程—制药化工]