复发性流产患者凝血相关指标的改变与易栓症发生的相关性  

The relationship between coagulation function and thrombophilia in patients with recurrent miscarriage

作　　者：刘劲松[1] 赖晓霏[1] 

机构地区：[1]重庆医科大学附属第一医院检验科,400016

出　　处：《检验医学与临床》2013年第23期3097-3098,共2页Laboratory Medicine and Clinic

基　　金：国家临床重点专科建设项目经费资助(财社[2010]305号)

摘　　要：目的探讨凝血、抗凝血指标和血小板等有关指标的改变与复发性流产发生的意义。方法选择30例正常足月妊娠妇女和50例复发性流产疾病患者,对活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、凝血酶时间(TT)和抗凝血酶Ⅲ(ATⅢ)以及血小板计数(PLT)进行检测和统计分析。结果复发性流产疾病组与正常足月妊娠组相比,PT、APTT、FIB、ATⅢ、PLT、TT差异均无统计学意义(P>0.05);D-二聚体两组差异有统计学意义(P<0.05)。结论联合检测凝血、抗凝血指标说明复发性流产疾病孕妇比正常孕妇具有更高的凝血状态,有血栓形成倾向。Objective To investigate the relationship between the coagulation function and thrombosis in pa- tients with recurrent spontaneous abortion（RSA）. Methods The prothrombin time（PT） ,activated partial thrombo- plastin time（APTT）, thrombin time（TT）, fibrinogen（FIB）, antithrombin Ⅲ （AT Ⅲ ）, platelet count（PLT） were test- ed and analyzed in 30 normal pregnant women in the third trimester and 50 pregnant women with RSA. Results Compared with the normal pregnant women, the levels of PT, APTT, FIB, AT Ⅲ, PLT, TT in the pregnant women with spontaneous abortion disorders was no significont differences（P〈 0.05）, D-dimer has significont differences （P 〈0.05）. Conclusion There are thrombophilia in pregnant women with spontaneous abortion disorders.

关 键 词：复发性流产疾病 凝血功能 易栓症 

分 类 号：R714.21[医药卫生—妇产科学]