硫酸钙/骨基质明胶在修复兔尺骨骨缺损中的实验研究  

Experimental study on CS/BMG biodegradable composite artificial materials in repairing bone defects of rabbit ulna

作　　者：孙翊夫[1] 夏鹏[1] 叶开其[2] 陈健[3] 

机构地区：[1]吉林大学中日联谊医院骨科,吉林长春130033 [2]吉林大学超分子结构与材料国家重点实验室,吉林长春130012 [3]吉林大学动物实验中心,吉林长春130062

出　　处：《检验医学与临床》2013年第23期3110-3111,共2页Laboratory Medicine and Clinic

基　　金：吉林省产业技术研究与开发项目(3J112P553430)

摘　　要：目的探讨硫酸钙/骨基质明胶可降解复合人工材料用于兔尺骨骨缺损的修复效果。方法选取已建立尺骨缺损模型家兔30只,采用随机数字表法将其分为3组,即空白对照组、单纯硫酸钙组及硫酸钙/骨基质明胶组,比较3组家兔术后12周骨痂形成率、骨性修复率及双轨征出现率、骨缺损修复X线片评分、尺骨扭转强度等。结果硫酸钙/骨基质明胶组骨痂形成率为93.33%、骨性修复率为86.67%、双轨征出现率为93.33%、骨缺损修复X线片评分(11.85±2.14)分、尺桡骨扭转强度(0.87±0.13)N×M,5项均明显高于单纯硫酸钙组和空白对照组,差异有统计学意义(P<0.05)。结论硫酸钙/骨基质明胶可降解复合人工材料,用于兔尺骨骨缺损修复效果显著,可有效促进骨痂形成及骨结构修复。Objective To explore the reparative effect of CS/BMG biodegradable artificial material on the de- fect of rabbit ulna bone. Methods Thirty rabbits on which ulna defect model had been established were selected, di- vided into three groups that normal control group, pure CS treatment group and CS/BMG group by using the random number table method,then compared these datas that bone callus formation rate, bony rate, rate of dual track ap- peared,bone defect repair X-ray score,ulna torsional stresses among three groups in the following 12 weeks. Results CS/BMG group bony callus formation rate, estoration rate, the double-track sign rate , bone defect repair X-ray score, ulna torsional stresses were 93.3% ,86.7% ,93.3%, （11.85±2.14）, （0.87±0.13）N× M, which were higher than the pure CS group and blank control group （P^0.05）. Conclusion The reparative effect of CS/BMG biodegradable artificial material on the defect of rabbit ulna bone is remarkable.

关 键 词：硫酸钙 骨基质明胶 可降解复合人工材料 骨缺损 修复 

分 类 号：R318.08[医药卫生—生物医学工程]