产超广谱β内酰胺酶大肠埃希菌耐药性分析  

Analysis about the drug resistance of e.coli producing extended spectrum β lactamase

作　　者：陈灿锋[1] 周伟[1] 梁有卓[1] 

机构地区：[1]广东省深圳市宝安区西乡人民医院检验科,518102

出　　处：《检验医学与临床》2013年第23期3116-3117,3119,共3页Laboratory Medicine and Clinic

基　　金：广东省深圳市宝安区2011年科技立项(20110464)

摘　　要：目的了解深圳地区2011～2013年住院患者产超广谱β内酰胺酶（ESBLs）大肠埃希菌的感染情况，为临床治疗及预防产ESBLs大肠埃希菌引起的感染提供警示。方法对2011年5月至2013年3月感染大肠埃希菌的住院患者采集临床资料，进行药敏试验，并进行统计学分析。结果深圳市宝安区西乡人民医院在2011年5月至2013年3月住院患者中检出大肠埃希菌328株，ESBLs158株，阳性率为48．17％，产ESBLs大肠埃希菌检出较多的科室为泌尿外科28株，17．72％；标本最多的为尿液71株，占44．94％。ESBLs阳性菌株中，tem基因检出85例，检出率53．80％，其中TEM-1检出63例，占74．12％。产ESBLs大肠埃希菌对各种抗菌药物均产生耐药。结论产ESBLS大肠埃希菌耐药明显，tern基因型以TEM-1为主。Objective To understand the status of effection with e. coli producing extended spectrum β lacta- mase（ESBLs） about the hospitalized patients in Shenzhen city,in order to provide basis for clinical treatment and pre- vention. Methods The clinical data and drug sensitive test result of the hospitalized patients infected with e. coli were collected and analyzed from May in 2011 to March in 2013. Results Between the results in our hospital in hospital ized patients, detected 328 cases of e. coli, ESBLs158 example, the positive rate of 48.1 7 %, produce ESBL e. coli de- tected more department of urology（28 cases, 17.72 % ）, the largest specimens was urine（71 cases, 44.94 % ） ; During the ESBLs positive strains,TEM genes detected in 85 cases,the positive rate of 53.80 % ,of which TEM-1 detected in 63 cases,accounting for 74. 12 %;were resistant to various antibiotics. Conclusion E. coli producing ESBLs resist- ance is apparent,should be took seriously.

关 键 词：超广谱Β-内酰胺酶 大肠埃希菌 耐药性 

分 类 号：R181.34[医药卫生—流行病学]