精液参数对宫腔内人工授精妊娠率的影响  

Effects of semen parameters on pregnancy rate of intrauterine insemination

作　　者：苏宁[1] 王维[1] 何燕[1] 曾艳华[1] 黄婷婷[1] 彭娅娅[1] 夏薇[1] 

机构地区：[1]广州市第一人民医院生殖健康与不孕症专科,广东广州510180

出　　处：《国际检验医学杂志》2013年第23期3154-3155,3157,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨处理后前向运动精子总数（PTMS）及精子正常形态对宫腔内人工授精（IUI）妊娠率的影响。方法收集接受了共417周期IUI治疗的216对不孕夫妇。按处理前精子形态,将其分为形态正常组（正常形态精子百分比：〉15%,n=45）、轻度畸形组（正常形态精子百分比：〉10%-15%,n=103）、中度畸形组（正常形态精子百分比：〉5%-10%,n=186）和重度畸形组（正常形态精子百分比：≤5%,n=83）。根据PTMS将其分为5组,第Ⅰ组：PTMS〈2×106,第Ⅱ组：2×106≤PTMS〈5×106,第Ⅲ组：5×106≤PTMS〈10×106,第Ⅳ组：10×106≤PTMS〈20×106,第Ⅴ组：PTMS≥20×106。比较各组妊娠率。结果 216对不孕夫妇临床妊娠73例,周期临床妊娠率17.50%。第Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ组患者的临床妊娠率分别为3.3%、15.8%、24.1%、15.0%和21.4%。形态正常组、轻度畸形组、中度畸形组和重度畸形组患者的临床妊娠率分别为20.0%、20.4%、19.4%和8.4%。结论当PTMS〈5×106或正常形态精子百分比低于5%时,IUI妊娠率显著下降。Objective To explore the effects of processed total motile sperm count（PTMS）and normal sperm morphology on pregnancy rate of intrauterine insemination（IUI）.Methods 216 infertile couples who had accepted total of 417 cycles of IUI treat- ment were enrolled.According to sperm morphology before processing,they were divided into normal morphology group（percentage of normal sperm morphology：15%,n=45）,mild deformity group（percentage of normal sperm morphology：10%-15%,n= 103）,moderate deformity group（percentage of normal sperm morphology：5%-10%,n=186）and severe deformity group（per- centage of normal sperm morphology：≤5%,n=83）.According to PTMS,they were divided into 5groups：groupⅠ：PTMS2× 106,groupⅡ：2×106≤PTMS5×106,groupⅢ：5×106≤PTMS10×106,groupⅣ：10×106≤PTMS20×106 and groupⅤ： PTMS≥20×106.Pregnant rates in each group were compared.Results A total of 73 cases were found to be clinically pregnant a- mong 216 infertile couples,with 17.50% of clinical pregnant rate per cycle.The clinical pregnant rates of patients in groupⅠ,Ⅱ, Ⅲ,Ⅳ,Ⅴ were 3.3%,15.8%,24.1%,15.0%and 21.4%,respectively,and those of patients in normal morphology group,mild deformity group,moderate deformity group and severe deformity group were 20.0 %,20.4 %,19.4 % and 8.4%,respectively. Conclusion Pregnant rates of IUI decreases significantly when PTMS is less than 5×106 or percentage of normal sperm morpholo- gy is less than 5%.

关 键 词：前向运动精子总数 精子形态 宫腔内人工授精 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]