乙型肝炎病毒e抗原S/CO值与HBV-DNA浓度的关系  

The relationship of S/CO value of hepatitis B virus e antigen and concentration of HBV-DNA

作　　者：昝丽娜[1] 孙峰[1] 张秀芳[1] 雷婷[1] 

机构地区：[1]亳州市人民医院检验科,安徽亳州236800

出　　处：《国际检验医学杂志》2013年第23期3156-3157,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨乙型肝炎病毒e抗原（HBeAg）S/CO值与乙型肝炎病毒（HBV）-DNA浓度的关系。方法采集306例乙型肝炎病毒表面抗原（HBsAg）阳性患者的血清样本。采用雅培i2000化学发光免疫分析仪进行HBeAg定量检测,采用ABI7300实时荧光定量PCR仪进行HBV-DNA定量检测。结果 306例HBsAg阳性的血清标本中,HBeAg阳性177例（57.84%）;HBeAg阴性而HBV-DNA阳性24例（7.84%）;HBV-DNA阴性而HBeAg阳性56例（18.30%）。HBV-DNA浓度为103-107 IU/mL,HBeAg与HBV-DNA浓度呈正相关（r〉0.3,P〈0.05）。结论 HBV-DNA与HBeAg联合检测可更好地为临床提供诊疗依据。Objective To investigate the relationship of S/CO value of hepatitis B virus e antigen（HBeAg）and concentration of hepatitis B virus（HBV）-DNA.Methods 306 samples of hepatitis B virus surface antigen（HBsAg）-positive serum were collected. Abbott i2000 chemiluminescence immunoassay analyzer was employed to detect HBeAg quantitatively,and ABI 7300 real-time PCR instrument was used to detect HBV-DNA quantitatively.Results Among 306 cases of HBsAg-positive serum samples,177 cases（57.84%）were found HBeAg-positive.24 cases（7.84%）were found HBeAg-negative and HBV-DNA-positive.56 cases（18.30%）were found HBV-DNA-negative and HBeAg-positive.HBV-DNA concentrations were from 103 IU/mL to 107 IU/mL. HBeAg was positively correlated with HBV-DNA concentration（r0.3,P〈0.05）.Conclusion Joint detection of HBV-DNA and HBeAg can provide a basis for clinical diagnosis and treatment.

关 键 词：肝炎e抗原 乙型 肝炎病毒 乙型 聚合酶链反应 化学发光测定法 

分 类 号：R446.6[医药卫生—诊断学]