冠心病PCI术后再狭窄患者IL-18基因多态性的研究  

A research of IL-18 gene polymorphism of patients with coronary heart disease suffering in-stent restenosis after PCI

作　　者：刘文卫[1,2] 江华[1,3] 刘永胜[1,2] 李婷[1,2] 王萍[1,2] 王炜娜[1,2] 赵玉勤[1,2] 周登明[1,2] 朱通建[1,2] 

机构地区：[1]湖北文理学院附属医院 [2]襄阳市中心医院心内科,湖北襄阳441021 [3]襄阳市中心医院检验科,湖北襄阳441021

出　　处：《国际检验医学杂志》2013年第23期3166-3167,共2页International Journal of Laboratory Medicine

摘　　要：目的研究白细胞介素-18(IL-18)基因多态性对冠心病患者经皮冠状动脉介入术(PCI)术后支架内再狭窄(ISR)易感性的潜在影响。方法将PCI术后的241例有再发缺血临床症状的冠心病患者作为研究对象,并根据冠状动脉造影结果分为支架内再狭窄(ISR)组(ISR组,n=68)和非ISR组(n=173),另选择109例排除冠心病的人群作为对照组。采用聚合酶链反应对IL-18基因型进行检测,同时测定血清IL-18浓度。结果 ISR组、非ISR组患者G等位基因频率分别为0.93、0.83,二者明显高于对照组(0.73,P<0.01),ISR组患者的G等位基因频率明显高非ISR组(P<0.01)。ISR组、非ISR组患者GG基因型频率分别为0.87、0.69,二者明显高于对照组(0.54,P<0.01),ISR组患者GG基因型频率明显高非ISR组(P<0.01)。ISR组、非ISR组患者血清IL-18浓度分别为(309.39±86.75)、(245.37±59.04)ng/L,明显高于对照组[(138.41±47.28)ng/L](P<0.01),ISR组患者血清IL-18浓度明显高于非ISR组(P<0.01)。结论 IL-18启动子-137G/C基因多态性可能会影响血清IL-18浓度及PCI术后再狭窄发生的易感性。Objective To study the potential impacts of interleukin-18（IL-18） gene polymorphism on in-stent restenosis（ISR） susceptibility of patients with coronary heart disease after percutaneous coronary intervention（PCI）.Methods 241 patients with coronary heart disease suffering clinical symptoms of recurrent ischemia after PCI were served as research objects and were divided into in-stent restenosis（ISR） group（n=68） and non-ISR group（n=173） according to the results of coronary angiography.Another 109 people excluding coronary heart disease were served as control group.Polymerase chain reaction was employed to detect IL-18 genotypes and its serum concentration.Results G allele frequencies of patients in ISR group and non-ISR group were 0.93,0.83, respectively,which were both markedly higher than that in control group（0.73,P〈0.01）.G allele frequencie of patients in ISR group was obviously higher than that in non-ISR group（P〈0.01）.GG genotype frequencies of patients in ISR group and non-ISR group were 0.87,0.69,respectively,which were both markedly higher than that in control group（0.54,P〈0.01）.GG genotype frequencie of patients in ISR group was obviously higher than that in non-ISR group（P〈0.01）.Serum IL-18 concentration of pa- tients in ISR group and non-ISR group were（309.39±86.75）,（245.37±59.04）ng/L,respectively,which were significantly higher than that in control group[（138.41±47.28）ng/L]（P〈0.01）.Serum IL-18concentration of patients in ISR group was obviously higher than that in non-ISR group（P〈0.01）.Conclusion Polymorphism of IL-18 promoter-137G/C may affect serum IL-18 concentration and ISR susceptibility after PCI.

关 键 词：白细胞介素8 多态性 单核苷酸 冠状动脉疾病 支架内再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]