有机胺改性海藻酸钠凝胶微球的制备及对药物的缓释作用  

STUDY ON PREPARATION AND APPLICATION OF SODIUM ALGINATE HYDROGEL MODIFIED BY ORGANIC AMINE

作　　者：许同桃[1] 高健[2] 杨姗姗[1] 

机构地区：[1]连云港职业技术学院医药与化学工程学院,江苏连云港222006 [2]江苏省海洋资源开发研究院,江苏连云港222006

出　　处：《海洋湖沼通报》2013年第4期130-134,共5页Transactions of Oceanology and Limnology

基　　金：连云港市科技局农业攻关项目(CN1211);江苏省海洋资源开发研究院开发课题(JSIMR11B01)资助

摘　　要：通过正己胺、正庚胺对海藻酸钠进行疏水改性,采用乳化-内部凝胶化技术分别制得负载小分子抗肿瘤药物β-榄香烯和小分子抗病毒药物阿德福韦的改性海藻酸钠凝胶微球,通过色谱法考察体外释放性能。正己胺、正庚胺改性海藻酸钠凝胶微球对药物β-榄香烯和阿德福韦的负载能力提高,且具有优良的缓释性能。改性凝胶微球对两种药物的包埋率都超过85%,48h体外累释放率超过55%。Abstract： Sodium alginate was hydrophobically modified through hexyl amine and heptyl amine. I,oad of small molecular anticancer drugs β-Elemene and antiviral drugs adefovir modified alginate gel micro- spheres were prepared by emulsification-internal gelatification technology, and In vitro drug release property was examined using gas chromatography. The modified alginate hydrogel has higher capacity and better sustained release to β-Elemene and adefovir than unmodified alginate hydrogel, respectively.

关 键 词：正己胺 正庚胺 海藻酸钠 凝胶 阿德福韦 Β-榄香烯 

分 类 号：R915[医药卫生—微生物与生化药学]