2008—2012年广西中医药大学第一附属医院革兰阴性菌的分布及耐药性分析  

Analysis on distribution and drug resistance of Gram-negative bacteria in First Affiliated Hospital of Guangxi University of Chinese Medicine from 2008 to 2012

作　　者：陶文[1] 梁业飞[2] 

机构地区：[1]广西中医药大学第一附属医院药学部,广西南宁530023 [2]钦州市第一人民医院药剂科,广西钦州535000

出　　处：《现代药物与临床》2013年第6期970-973,共4页Drugs & Clinic

摘　　要：目的了解广西中医药大学第一附属医院临床常见革兰阴性菌的分布及耐药性变迁,以指导临床合理使用抗菌药物。方法对2008—2012年广西中医药大学第一附属医院临床分离的常见革兰阴性菌的菌株分布及药物敏感性变化进行回顾性调查。结果共分离出常见的革兰阴性菌8 411株,主要以大肠埃希菌和肺炎克雷伯菌为主,分别占28.7%、21.1%;铜绿假单胞菌和鲍曼不动杆菌检出率分别18.4%、15.1%。大肠埃希菌和肺炎克雷伯菌超广谱β-内酰胺酶(ESBLs)的平均检出率分别为51.2%、34.3%。阴沟肠杆菌、肺炎克雷伯菌和大肠埃希菌对碳青霉烯类抗菌药物总体上有较高的敏感性。铜绿假单胞菌、鲍曼不动杆菌对多数抗菌药物高度耐药,且呈逐年上升趋势。结论临床常见革兰阴性菌对常用抗菌药物耐药严重,应加强革兰阴性杆菌耐药性的动态监测,以指导临床进行合理规范的抗感染治疗。Objective To investigate First Affiliated Hospital of Guangxi the distribution and antimicrobial resistance of clinical common Gram-negative bacteria in the University of Chinese Medicine from 2008 to 2012, and to instruct the reasonable clinical application of antibiotics. Methods The distribution of Gram-negative bacteria and antibiotic sensibility in the First Affiliated Hospital of Guangxi University of Chinese Medicine from 2008 to 2012 were reviewed, retrospectively. Results All of 8 411 Gram-negative bacteria were isolated, the main strains were Escherichia coli （28.7%）, Klebsiella pneumoniae （21.1%）, Pseudomonas aeruginosa （18.4%） and Acinetobacter baumannii （15.1%）. E. coli and K. pneumoniae extended spectrum beta lactamases （ESBL）（＋）, were 51.2% and 34.3%, respectively. The antibiotic sensibility result was analyzed, E. coli, K. pneumoniae, and Enterobacter cloacae kept higher sensibility to imipenem, meropenem, and piperacillin/tazobactam. R aeruginosa and A. baumannii kept higher resistance to most antibiotics and increased year by year. Conclusion The drug resistance status of common clinical Gram-negative bacteria is more and more serious. We should strengthen the detecting of pathogens and monitoring of bacterial drug resistance, so as to instruct the clinicians to have anti-infectious remedy reasonably and normatively.

关 键 词：抗菌药物 抗药性 革兰阴性菌 微生物敏感性试验 

分 类 号：R978[医药卫生—药品]