原小檗碱类化合物的药理作用研究进展  

Advances in studies on pharmacological actions of proberberine

作　　者：曹阳[1] 刘雯清[1] 朴光春[2] 姜远英[1,3] 曹永兵[1,3] 

机构地区：[1]福建中医药大学药学院中药学教研室,福建福州350000 [2]延边大学药学院,吉林延吉133000 [3]第二军医大学药学院新药研究中心,上海200433

出　　处：《现代药物与临床》2013年第6期1012-1017,共6页Drugs & Clinic

摘　　要：原小檗碱类化合物是一类异喹啉生物碱,广泛存在于多个种属的植物中,在化学结构上具有相似的骨架结构,根据骨架结构和取代基团的不同,可分为原小檗碱型、双苄基异喹啉型和阿扑芬型等。目前,对小檗碱、小檗红碱和巴马汀等化合物的药理研究较为广泛。已有研究和临床应用结果表明,原小檗碱类化合物具有抗肿瘤、降血糖、抗炎、降血脂、抗病原微生物、抗老年痴呆、抗心律失常等广泛的药理活性。综述了该类化合物的药理活性研究进展,并总结分析了可能的作用机制。The proberberine compound is an isoquinoline alkaloid with the similar backbone structures, which exists in a variety of plants. According to the different backbone structures and substituent groups, it can be divided into protoberberine alkaloids, bisbenzylisoguinoline alkaloids and apomorphine Fen alkaloids. The pharmacological effects of berberine, berberubine, palmatine have been widely studied. The results indicated that the proberberine compound has the function of antitumor, hypoglycemia, antiinflammation, hypolipemia, antibacterium, antivirus infection, Alzheimer＇s disease and antiarrhythmia. This review summarizes the pharmacological activities, and analyzes the pharmacodynamic mechanism of proberberine compound.

关 键 词：原小檗碱 药理活性 骨架结构 作用机制 

分 类 号：R285.6[医药卫生—中药学]