实验室重构流感病毒的生物安全问题  

Biosafety issues and public concerns on recombinant influenza viruses generated in the laboratories

作　　者：贾晓娟[1] 黄力勤[1] 刘文军[1] 

机构地区：[1]中国科学院微生物研究所中国科学院病原微生物与免疫学重点实验室,北京100101

出　　处：《生物工程学报》2013年第12期1736-1742,共7页Chinese Journal of Biotechnology

基　　金：公益性卫生行业科研专项(No.201302006)资助~~

摘　　要：流感病毒的跨种间传播是流感病毒研究的重要方面。部分研究者采取实验室重构流感病毒的方法,试图发现影响流感病毒跨种间传播的重要因子,这对揭示流感病毒跨种间传播的分子机制以及流感的防控和治疗具有重要意义,但重构流感病毒潜在的生物安全问题令人关注。文中重点讨论了目前实验室重构流感病毒的生物安全问题,建议从实验室防护和科研管理两方面重视并加强实验室重构流感病毒,特别是高致病流感病毒的生物安全管理工作。Understanding inter-species transmission of influenza viruses is an important research topic. Scientists try to identify and evaluate the functional factors determining the host range of influenza viruses by generating the recombinant viruses through reverse genetics in laboratories, which reveals the viruses＇ molecular mechanisms of infection and transmission in different species. Therefore, the reverse genetic method is a very important tool for further understanding the biology of influenza viruses and will provide the insight for the prevention and treatment of infections and transmission. However, these recombinant influenza viruses generated in laboratories will become the potential threat to the public health and the environment. In this paper, we discussed the biological safety issues of recombinant influenza viruses and suggested we should set up protocols for risk management on research activities related to recombinant highly pathogenic influenza viruses.

关 键 词：重构 流感病毒 实验室生物安全 风险管理 

分 类 号：R373[医药卫生—病原生物学] S852.65[医药卫生—基础医学]