剪切波组织定量技术评估肝弹性硬度的多因素回归分析：初步临床研究  

A preliminary clinical study on the assessment of liver fibrosis by elastography point quantification technique with multivariate regression analysis

作　　者：丁红[1] 马姣姣[1] 王文平[1] 毛枫[1] 徐晨[1] 黄备建[1] 

机构地区：[1]复旦大学附属中山医院超声科,上海200032

出　　处：《中华超声影像学杂志》2013年第12期1041-1044,共4页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金项目（30872409）;上海市重点学科建设项目（B112）

摘　　要：目的初步分析剪切波组织定量（elastography point quantification，ElastPQ）技术评估肝弹性硬度的可行性及其主要影响因素。方法使用Philips iU Elite超声仪对235例肝肿瘤患者的右叶肝实质进行弹性硬度检测，获得ElastPQ值，与组织病理学的肝纤维化分级（S）、炎症程度（G）和脂肪变程度以及性别和年龄因素相比较，采用多重线性回归的逐步回归方法筛选出与ElastPQ弹性测值密切相关的因素，并获得拟合方程。结果ElastPQ弹性测值随着肝纤维化程度和炎症活动程度的加重而增大，两者相关性具有统计学意义（r=0．75，P=0．00；r=0．64，P=0．00）；而脂肪变程度、性别和年龄因素与ElastPQ弹性测值无明显相关（P〉0．05）。ElastPQ对肝纤维化程度和炎症活动程度的回归方程为：ElastPQ=1．205S＋1．075G＋4．537。结论ElastPQ技术可有效检测肝组织弹性硬度，其中肝纤维化程度和炎症活动程度是ElastPQ弹性测值的主要影响因素。Objective To preliminarily evaluate the feasibility of elastography point quantification （ElastPQ） technology in the determination of liver stiffness as well as its impact factors. Methods Amount to 235 patients with liver neoplasms underwent liver stiffness measurement in the right lobe of liver using an ultrasound scanner （iU Elite,Philips）. ElastPQ values were obtained and compared with the liver fibrosis stage （S）, the grade of necroinflammatory activity （G） and steatosis assessed histologically as well as gender and age. The factors related to ElastPQ values were explored by stepwise regression in multiple linear regression analysis and the regression equation was established. Results In the multiple linear regression model of ElastPQ values,liver fibrosis and necroinflammatory activity were associated with ElastPQ （ P〈0.05） while other factors including age,gender and hepatic steatosis had no effect on ElastPQ statistically （P 〉0.05）. The equation of linear regression was ElastPQ = 1. 205S ＋ 1. 075 G ＋ 4. 537. Conclusions ElastPQ technique is a reliably noninvasive tool in the liver stiffness measurement. Liver fibrosis and necroinflammatory activity are the main factors affecting liver stiffness measured by ElastPQ.

关 键 词：超声检查 肝硬化 弹性 剪切波组织定量 

分 类 号：R445.1[医药卫生—影像医学与核医学]