男性血清胰岛素样生长因子I水平与心血管危险因素的关系  

Relationship of serum insulin.like growth factor - I level with cardiovascular risk factors in male subjects

作　　者：宋青青[1] 康冬梅[1] 

机构地区：[1]安徽医科大学附属省立医院干部病房,合肥230001

出　　处：《中华内分泌代谢杂志》2013年第12期1037-1039,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：安徽省科技计划项目（08020303073、12010402134）

摘　　要：采用ELISA法测定308名年龄20～79岁的健康男性血清胰岛素样生长因子I（IGF—I）水平。结果显示，308名健康成人血清IGF．I的浓度平均为（140．61±39．04）ng／ml，以20～29岁组为基准，其余各组与之比较均明显降低（P〈0．05）。调整年龄后的偏相关分析结果显示，血清IGF—I水平与甘油三酯（TG）、低密度脂蛋白胆固醇、收缩压、餐后2h血糖、c反应蛋白呈负相关（P〈0．05或P〈0．01），与高密度脂蛋白胆固醇（HDL—C）呈正相关（P〈O．01）。将IGF—I水平按照四分位间距分为4组，结果显示收缩压、TG随IGF—I水平增高有下降的趋势（P〈0．01），HDL—C随IGF—I水平增高有升高的趋势（P〈0．01）。＂The level-oiserum insulin-like growth factor- I （ IGF- I ） in 308 healthy men aged 20 to 79 years was measured by ELISA. and fasting blood glucose （ FBG）, two hours postprandial blood glucose （2hPG）, fasting insulin （ FINS）, high density lipoprotein cholesterol （ HDL-C ） , low-density lipoprotein cholesterol （ LDL-C ） and C reactive protein （CRP） were determined at the same time. The results showed that the average level of serum IGF- I was 140.61 ＋ 39.04 ng/ml. Compared with the group aged 20 - 29 years, the levels of IGF- I in other age groups were all loweded （ P〈O. 05 ）. After adjusting for age, partial correlate analysis showed that the level of serum IGF- I was negatively correlated with triglyceride （ TG）, LDL-C, systolic blood pressure, 2hPG, CRP （ P 〈 0.05 or P 〈 0. O1 ） , and positively correlated with HDL-C （ P〈0.01 ） o Based on the quartile levels of IGF- I pressure and TG were decreased and HDL-C was increased with increased IGF- I levels（P〈0.01 ）.

关 键 词：男性 胰岛素样生长因子I 心血管危险因素 

分 类 号：R54[医药卫生—心血管疾病]