原发性醛固酮增多症的遗传学研究现状  

Genetic aspects in primary aldosteronism

作　　者：李红建[1] 李南方[1] 

机构地区：[1]新疆维吾尔自治区人民医院高血压中心,新疆高血压研究所,第一作者现在新疆医科大学第五附属医院,830001

出　　处：《中华内分泌代谢杂志》2013年第12期1070-1072,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81260129）

摘　　要：原发性醛固酮增多症是常见继发性高血压的原因之一，且其较原发性高血压有更高的靶器官损害和心血管事件的发生率。探明原发性醛固酮增多症的发病机制，有助于开发原发性醛固酮增多症患者的靶向性治疗，从而改善其预后。目前研究已阐明家族性高醛固酮血症I型的发病机制，而对其他亚型发病机制的研究仍在进行中。本文将对原发性醛固酮增多症的分子遗传学研究现状进行总结。Primary aldosteronism （PA） is one of the common forms of secondary hypertension. Compared with essential hypertension patients, PA patients have a higher incidence of target organ damage and cardiovascular events. Elucidation of the underlying molecular mechanisms will likely aid the development of targeted treatments and improve prognosis for PA patients. At present, studies have elucidated the pathogenesis of familial hyperaldosteronism type I, while the study of the pathogenesis of other subtypes is still in progressing. This review introduces the current studies on the molecular genetics of nrimarv aldosteronism.

关 键 词：原发性醛固酮增多症 发病机制 醛固酮合酶 KCNJ5 

分 类 号：R586.24[医药卫生—内分泌]