临沂地区1426例手足口病流行病学及临床特征分析  

Epidemiological survey and clinical analysis of 1426 patients with hand, foot and mouth disease in Linyi

作　　者：王经伟[1] 高帅[2] 高峰[1] 杨朝晖[1] 尹爱红[3] 王凯[2] 

机构地区：[1]临沂市人民医院感染科,276003 [2]山东大学齐鲁医院肝病科 [3]山东省疾病预防控制中心

出　　处：《中华实验和临床病毒学杂志》2013年第6期417-419,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨山东省临沂地区手足口病的流行病学及临床特征，为制定本地区疾病防治措施提供依据。方法制定手足口病观察项目表，采集2012年4—9月山东省临沂地区1426例手足口病患者的流行病学及临床特征，果用描述流行病学方法进行分析。结果临沂地区手足口病发病高峰为5月，以3岁以下散居及幼托儿童为主，发病率男童多于女童，农村高于城镇。临床表现主要包括发热、皮疹等，重症患儿可发生多系统并发症。辅助检查可见白细胞及中性粒细胞比值增高等特征。EV71为重症病例的主要病原，占重症病例的77．21％。结论山东省临沂地区手足口病流行具有明显季节性、人群性及地区性。针对本地区流行病特点，制定区域特异性防治措施至关重要。Objective To investigate the epidemiological and clinical characteristics of hand, foot and mouth diseases （HFMD） in Linyi area, which may provide insight for developing disease control therapy. Methods Make an observation table, then record and analyze the epidemiological and clinical characteristics of HFMD in Linyi area. The data was then descriptively analyzed. Results The highest peak of HFMD incidence was detected at May. Most of the patients were children less than 3 years old and there was a tendency of HFMD in boys and children living in rural and suburban areas. Clinical symptoms mainly included fever and skin rash. Severe patients can also have various complications. Laboratory test usually showed elevated leukocyte count and neutrophil percentage. The major pathogens causing severe HFMD cases were enterovirus 71 （EV71） , accounting for 77.21% of all cases. Conclusion HFMD of Linyi area showed varied epidemiological characteristics at different seasons, areas and population. Developing control therapy according to the specific epidemiological and clinical characteristics is essential for the management of HFMD in Linyi area.

关 键 词：手足口病 流行病学 肠道病毒属 柯萨奇病毒感染 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]