HBeAg阴性与阳性慢性乙型肝炎患者临床分析  

Analysis of clinical characteristics between FIBeAg-negative and HBeAg-positive patients with chronic hepatitis B

作　　者：席宏丽[1] 李敏然[1] 鲍毅[1] 徐小元[1] 

机构地区：[1]北京大学第一医院感染性疾病科,100034

出　　处：《中华实验和临床病毒学杂志》2013年第6期472-473,共2页Chinese Journal of Experimental and Clinical Virology

基　　金：北京市科委2012年度科技计划重大项目（D121100003912003）

摘　　要：目的观察乙肝病毒c抗原（HBeAg）阴性与阳性慢性乙型肝炎患者在年龄、ALT、乙肝病毒脱氧核糖核酸（HBVDNA）定量方面的特点。方法回顾性分析125例慢性乙型肝炎患者的临床资料，根据HBeAg表达情况分为HBeAg阴性与阳性慢性乙型肝炎两组，对两组患者的年龄、ALT和HBVDNA进行统计学分析。结果125例慢性乙型肝炎患者中，HBeAg阴性组24例，占19．2％；HBeAg阳性组101例，占80．8％。两组在平均年龄、HBVDNA之间比较，差异具有统计学意义；ALT之间比较没有统计学意义。在HBeAg阴性组中，HBVDNA定量较低，随着病毒载量的增高，ALT异常的数量呈下降趋势；在HBeAg阳性组中，HBVDNA定量较高，随着病毒载量的增高，ALT异常的数量大致呈上升趋势。结论HBeAg阴性慢性乙型肝炎患者年龄较HBeAg阳性患者高，ALT、HBVDNA定量水平低于HBeAg阳性者。随着病毒载量的增高，ALT异常的数量呈下降趋势，而后者则相反。Objective To observe the characteristics of age, alanine aminotransferase （ALT） and hepatitis B virus DNA （HBV DNA） quantitative between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B. Methods The clinical datas of 125 patients with chronic hepatitis B were analyzed retrospectively. According to the expression of HBeAg, divided the chronic hepatitis B patients into two groups： HBeAg-negative and-positive. The datas of age, ALT and HBV DNA were analyzed by statistical methods. Results Among 125 patients, 24 cases were HBeAg-negative group accounting for 19. 2% ; 101 cases were HBeAg-positive group accounting for 80. 8%. The difference between two groups in average age and HBV I）NA was significant, the comparison between ALT of two groups has no statistical significance. In HBeAg-negative groups, HBV DNA quantitative is lower, as the viral load increase, the number of abnormal ALT show a downward trend; In HBeAg positive group, HBV DNA quantitative is higher, as the viral load increase, the ALT abnormal quantity generally show a upward trend. Conclusions The age of HBeAg- negative chronic hepatitis B patients is larger than the HBeAg-positive patients, the level of ALT, HBV DNA quantitative in HBeAg-negative chronic hepatitis B patients lower than the HBeAg-positive patients, and as the viral load increase, the ALT abnormal number is on the decline, while the latter is opposite.

关 键 词：肝炎 乙型 慢性 肝炎e抗原 乙型 DNA 

分 类 号：R512.62[医药卫生—内科学]