糖化低密度脂蛋白水平与冠脉粥样硬化程度的关系  

Association between glycosylated low density lipoprotein and degree of coronary atherosclerosis

作　　者：马向波 王彦富[2] 李清贤[2] 

机构地区：[1]山东大学医学院,济南250012 [2]济宁医学院附属医院心内一科,山东济宁272000

出　　处：《山东大学学报（医学版）》2013年第12期51-54,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨糖化低密度脂蛋白(G-LDL)水平与冠脉粥样硬化程度的关系。方法通过冠脉造影检查,选择糖尿病冠脉造影阴性(DM-NCHD)患者49例、糖尿病冠脉造影阳性(DM-CHD)患者50例及非糖尿病冠脉造影阴性(NC)患者50例。采用氯化硝基四氮唑蓝法检测DM-NCHD、DM-CHD及NC组的血清G-LDL水平。应用受试者工作特征曲线(ROC曲线)评价血清G-LDL的诊断效能和最佳诊断分界值。结果 DM-NCHD组G-LDL水平低于DM-CHD组(P<0.05),高于NC组(P<0.05)。血清G-LDL水平为50.45时,灵敏度为0.80,特异度为0.84。DM-CHD组G-LDL水平与冠脉粥样硬化程度(用Gensini评分表示)呈正相关(r=0.638,P=0.001)。结论DM-NCHD患者血清G-LDL水平明显低于DM-CHD患者,且G-LDL水平与冠脉粥样硬化程度呈正相关,G-LDL有望成为评价糖尿病患者冠脉粥样硬化风险的有效指标。Objective To investigate the relationship between glycosylated low density lipoprotein （G-LDL） degree of coronary angiography. Methods With reference to the results of coronary angiography examination, we selected 49 diabetic patients with negative coronary angiography results （DM-NCHD）, 50 diabetic patients with positive coronary angiography results （ DM-CHD）, and 50 non-diabetic patients with negative coronary angiography results （NC）. The G-LDL levels of the three groups were detected with nitrotetrazolium blue chloride. The diagnostic performance and optimum diagnostic boundary values of G-LDL in serum were evaluated with receiver operating characteristic curve （ROC curve）. Results G-LDL level of the DM-NCHD group was lower than that of the DM-CHD group （P 〈 0.05 ）, and tended to be higher compared to that of the NC group （ P 〈 0.05 ）. When G-LDL level was 50.45, the sen- sitivity and specificity were 0.80 and 0.84, respectively. The G-LDL level in the DM-CHD group was positively corre- lated with the degree of coronary atherosclerosis （ r = 0. 638, P = 0. 001 ）. Conclusion The G-LDL level in the DM-NCHD group is significantly lower than that in the DM-CHD group, and the G-LDL level in the DM-CHD group is positively correlated with the degree of coronary atherosclerosis, which indicates G-LDL may be an effective indicator to evaluate the risk of coronary atherosclerotic in patients with diabetes mellitus.

关 键 词：糖化低密度脂蛋白 冠脉造影阴性 糖尿病 冠脉粥样硬化 

分 类 号：R543.3[医药卫生—心血管疾病]