甲状腺功能与肥胖及代谢综合征的相关性分析  

Correlation between thyroid function and obesity as well as metabolic syndrome

作　　者：武传龙[1] 许良银[2] 侯新国[1] 赵汝星[1] 陈丽[1] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012 [2]江苏省常州市德安医院内分泌科,江苏常州213003

出　　处：《山东大学学报（医学版）》2013年第12期88-91,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨甲状腺功能与肥胖和代谢综合征(MS)的相关性。方法按照中华医学会糖尿病学分会(CDS2004)诊断标准随机选取MS患者44例(MS1组),按照2007《中国成人血脂异常防治指南》诊断标准随机选取MS患者42例(MS2组),另外随机选取单纯肥胖人群(单纯肥胖组)37例,3组分别与正常体质量健康人群(正常对照组,n=30)进行甲状腺功能(FT3、FT4、TSH)、空腹血糖、血脂(包括TG和HDL-C)以及年龄、体质量指数(BMI)、腰围、臀围、血压等指标的比较。结果与正常对照组相比,单纯肥胖人群及不同诊断标准下的MS患者的BMI、FT4和TSH均明显增高,差异有统计学意义(P<0.001,P<0.01,P<0.05);与正常对照组相比,MS1组和MS2组HDL-C和FT3降低、TG升高,差异有统计学意义(P<0.01,P<0.05)。结论甲状腺功能与肥胖及MS密切相关,甲状腺功能可作为评估肥胖人群代谢异常情况的重要指标之一。Objective To investigate the relationship between thyroid function and obesity, as well as the pathogenesis of metabolic syndrome （MS）. Methods A total of 44 MS subjects identified according to the criteria formulated by Chinese Diabetes Society （CDS2004）, 42 MS subjects identified with reference to Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults （2007）, 37 people with obesity, and 30 healthy controls were included in the research. Fasting venous blood was collected in the morning to detect the serum levels of FT3, FT4 and TSH. The age, waist circumference, hip circumference, blood pressure, blood glucose and lipids including total cholesterol, triglycer- ide, high and low density lipoprotein cholesterol and other related parameters were recorded and compared. Results Compared to health controls, the two MS groups and the obesity group had significantly higher serum levels of FT4 and TSH （P 〈0.01, P 〈0. 05, P 〈0. 001 ） ; the two MS groups had significantly lower HDL-C and PT3 levels but higher TG levels （P 〈 0.01, P 〈 0. 05 ）. Conclusion The thyroid function is closely related to obesity and MS, indicating that thyroid function may be an important indicator of metabolic disorder in obesity.

关 键 词：肥胖 代谢综合征 甲状腺功能 相关性 诊断标准 

分 类 号：R587.1[医药卫生—内分泌]