幽门螺杆菌感染在不同类型心房颤动中的差别  

The Correlation of Helicobacter Pylori Infection with Different Types of Atrial Fibril-lation

作　　者：王德昭[1] 李世敬[2] 王军[2] 陈步星[1] 

机构地区：[1]首都医科大学附属北京天坛医院,北京市100050 [2]北京市门头沟区医院,北京市102300

出　　处：《中国动脉硬化杂志》2013年第11期1023-1027,共5页Chinese Journal of Arteriosclerosis

基　　金：北京市优秀青年基金项目(2011D008017000002)

摘　　要：目的分析幽门螺杆菌(Hp)感染在五种类型心房颤动(AF)的差别,探讨Hp感染与不同类型AF的相关性。方法根据2010年ESC指南将AF分为首发AF、阵发性AF、持续性AF、长程持续性AF以及永久性AF五种类型。回顾性分析2007年1月至2013年4月住院治疗的AF患者285例;所有患者在院期间均进行了13C呼气试验测定以及血浆幽门螺杆菌抗体(Hp-IgG)的测定,同时收集病史、血常规、血生化、高敏C反应蛋白(hs-CRP)、左心房内径(LAD)、尿微量白蛋白(UMA)、糖化血红蛋白以及同型半胱氨酸(Hcy)等指标,分析Hp感染、hs-CRP水平、LAD等指标在各型AF中的差别。再按照AF发生的时间将五种类型的AF分为两组:短程AF(包括首诊AF、阵发性AF和持续性AF)和长程AF(包括长程持续性AF和永久性AF),应用Logistic回归分析,探讨Hp感染与AF的相关性。结果长程AF组Hp值、hs-CRP水平及LAD与短程AF组相比差异有显著性(P<0.05);Hp≥4‰、hs-CRP>5 mg/L及LAD>36 mm是长程AF患者的敏感指标。结论长程AF患者Hp值、hs-CRP水平及LAD明显高于短程AF患者;Hp≥4‰、hs-CRP>5 mg/L及LAD>36 mm与长程AF密切相关。Aim To analyze the difference of Hehcobacter pylzri （Hp） infection in five types of atrial fibrillation （AF） and to explore the correlation between Hp infection and the different types of AF. Methods According to the 2010 ESC guidelines, AF was divided into five types： initial AF, paroxysmal AF, persistent AF, long persistent AF and permanent AF. 285 cases of hospitalized AF patients were enrolled with a retrospective analysis from January 1,2007 to April 12, 2013. All patients were taken the examination of plasma antibody of Hp （IgG）, J3C urea breath test, blood routine, blood biochemistry, high sensitive C-reactive protein （hs-CRP）, left atrial diameter （LAD）, urinary microalbu- rain （ UMA）, glycosylated hemoglobin and plasma homocysteine （Hcy）. We analyzed the difference of Hp infection, hs- CRP level, LAD and other indicators in five types of AF. According to the time of occurrence, AF were divided into two groups： less than one year of AF （Group one： including initial AF, paroxysmal AF and persistent AF） and more than one year of AF （ Group two ： including long persistent AF and permanent AF）. Then, we explored the correlation between Hp infection and AF by the Logistic regression analysis. Results The value of ~3C urea breath test, hs-CRP and LAD in Group one were significantly different with that in Group two （P 〈 0.05 ）. r Hp ~〉4%~, hs--CRP 〉 5 mg/L and LAD 〉 36 mm were sensitive index of AF patients more than one year. Conclusion The value of J3C urea breath test, hs-CRP and LAD in patients with AF sustained over one year were significantly higher than that in patients with AF sustained in one year. Hp~〉4%~, hs-CRP 〉5 mg/L and LAD 〉36 mm were closely related to AF sustained more than one year.

关 键 词：幽门螺杆菌感染 高敏C反应蛋白 左心房内径 心房颤动 13C呼气试验 

分 类 号：R5[医药卫生—内科学]