晚期糖基化终末产物、臂-踝脉搏波传导速度与冠状动脉狭窄程度的相关性  

Relationship Between Advanced Glycation End Products,Brachial-ankle Pulse Wave Velocity and Severity of Coronary Artery Disease

作　　者：高锦雄[1] 梁碧霞[1] 彭海军[1] 严炳存[1] 李明光[1] 石延科[1] 

机构地区：[1]中山市博爱医院心内科,广东省中山市528403

出　　处：《中国动脉硬化杂志》2013年第11期1028-1032,共5页Chinese Journal of Arteriosclerosis

基　　金：中山市卫生局医学科研立项项目(J2011095)

摘　　要：目的探讨晚期糖基化终末产物(AGE)、动脉硬化与冠状动脉病变狭窄程度间的关系。方法采用VP1000动脉硬化检测仪测定105例冠状动脉轻中度狭窄患者、130例冠状动脉重度狭窄患者和150例年龄相当的健康对照者的臂-踝动脉脉搏波传导速度(baPWV),同时检测受试者外周血清中AGE含量。结果与健康对照者相比,冠状动脉轻中度狭窄患者血清AGE、baPWV均显著升高(P<0.001),且在冠状动脉重度狭窄患者中增高更明显(P<0.001);Logistic回归分析显示AGE、baPWV均为冠状动脉病变严重程度的一项重要危险因素(P<0.001);相关分析显示血清AGE水平与baPWV呈显著正相关(r=0.692,P<0.001)。结论血清AGE为冠状动脉病变狭窄程度的一项独立危险因素,可能在冠状动脉病变狭窄程度的发生发展过程中起一定作用。Aim To elucidate the relationship between advanced glycation end products （AGE）, arterial stiff- ness and the degree of coronary artery stenosis in Chinese Han patients. Methods The serum concentration of AGE was measured and the brachial-ankle pulse wave velocity （baPWV） was detected in 105 cases of mild/moderate coronary stenosis, 130 cases of serious coronary stenosis and 150 aged-matched control subjects. Results Serum AGE and baPWV were significantly higher in the mild/moderate coronary stenosis and serious coronary stenosis patients when com- pared with the control subjects （P 〈 0. 001 ）. In Logistic regression analysis, serum AGE and baPWV were independently associated with the degree of coronary artery stenosis （P 〈0. 001 ）. Further analysis showed that AGE was significantly and positively correlated with baPWV （ r = 0. 692, P 〈 0. 001 ）. Conclusions Serum AGE was an independent risk factor of the severity of coronary artery disease and might be involved in the development of coronary artery stenosis through inducing arterial stiffness.

关 键 词：晚期糖基化终末产物 臂-踝脉搏波传导速度 冠状动脉狭窄 

分 类 号：R5[医药卫生—内科学]