苯并噻唑类化合物对高脂模型小鼠抗氧化能力的影响  

Effect of Benzothiazole Derivatives on the Antioxidating Activities of High-fat Fed Mice

作　　者：花尔并[1] 王秋月[1] 王莹莹[1] 刘为铸 申婷婷[1] 

机构地区：[1]天津科技大学生物工程学院,天津300457

出　　处：《天津科技大学学报》2013年第6期5-8,共4页Journal of Tianjin University of Science & Technology

基　　金：国家自然科学基金面上项目(81072521);天津科技大学人才引进科研启动基金资助项目(20091204)

摘　　要：研究苯并噻唑类化合物TJ-1(2–间苯胺基苯并噻唑)、TJ-2(2–间苯胺基苯并噻唑–3,4,5–三甲氧基苯甲酰胺)、TJ-3(2–间苯胺基苯并噻唑–1H–吡唑–3–甲酰胺)对高脂模型小鼠抗氧化能力的影响.50只8周龄健康雄性C57BL/6,J小鼠适应性饲养1周后,根据体质量随机分为高脂组、白藜芦醇对照组、TJ-1组、TJ-2组和TJ-3组.高脂组喂饲相应高脂饲料,白藜芦醇对照组和各干预组小鼠喂饲高脂饲料并分别添加0.1%的白藜芦醇、TJ-1、TJ-2、TJ-3进行干预,干预12周后测定小鼠血清、肝脏和脑的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)和丙二醛(MDA)的水平.与高脂组相比,TJ-1、TJ-2、TJ-3、白藜芦醇各组小鼠血清、肝脏和脑的SOD、GSH-Px、CAT水平均高于高脂模型组,MDA水平低于高脂组.结果表明:苯并噻唑类化合物能改善高脂模型小鼠的抗氧化能力.The effect of benzothiazole derivatives TJ-1 （3- （benzo[d]thiazol-2-yl） benzenamine）, TJ-2 （N- （3- （benzo[d] thiazol- 2-yl） phenyl）-3,4,5-trimethoxybenzamide）, and TJ-3 （N- （3- （benzo[d]thiazol-2-yl） phenyl） -1 H-pyrazole-3-carboxamide） on the antioxidating activities of mice with high fat diet was studied. Fifty 8-week-old male C57BL/6 J mice were quaran- tined for 1 week. They were then randomly assigned to the following five groups according to body weight：high fat diet group,resveratrol control group,TJ-1 group,TJ-2 group and TJ-3 group. The levels of superoxide dismutase（SOD）, glutathione peroxidase（GSH-Px）,catalase（CAT）and malondialdehyde（MDA）were measured after the treatment which lasted for 12 weeks. Compared with the high fat diet group, the SOD, GSH-Px and CAT levels in the serum, liver and brain of the other 4 groups were higher, and the MDA levels were lower. Benzothiazole derivatives can improve the antioxidating activities of high fat mice.

关 键 词：苯并噻唑类化合物 白藜芦醇 抗氧化 

分 类 号：R962[医药卫生—药理学]