1例头孢克洛致急性胆汁淤积型药物性肝损伤儿童患者的药学监护  

Pharmaceutical care on a child patient with acute cholestatic drug-induced liver injury from cefaclor

作　　者：蒋杰[1] 张谊芳 劳国琴[1] 

机构地区：[1]绍兴市第六人民医院药剂科,浙江绍兴312000

出　　处：《中国药物应用与监测》2013年第6期318-320,322,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：1例11岁儿童患者,因服用头孢克洛4 d后出现尿黄、皮肤瘙痒入院。查肝功能异常,诊断为急性胆汁淤积型药物性肝损伤,给予保肝、退黄、降酶等对症治疗。针对患者未成年和肝损伤急性加重等特点,药学监护集中于保肝药物的合理选用、糖皮质激素个体化给药方案的制定、不良反应的监测以及药物不良相互作用的干预,同时通过用药教育提高患者用药依从性,减少潜在的用药风险。治疗4周后,患者肝功能恢复正常出院。One 11-year-old child patient with yellow urine and itching was hospitalized after taking cefaclor for 4 days. Clinical diagnosis was acute cholestatic drug-induced liver injury. Symptomatic treatments such as protecting liver function, depressing transaminase and abating jaundice were given to the patient after admission. Considering that the patient was a child and liver injury was acute exacerbation, pharmaceutical cares focused on rational selection of hepatoprotective drugs, establishment of glucocorticoid individualized treatment, adverse reactions monitoring and intervention of drug interaction. The patient＇s compliance increased and the potential medication risk decreased by medication education. Four weeks later, the patient was discharged with normal liver function.

关 键 词：头孢克洛 急性胆汁淤积型药物性肝损伤 临床药师 药学监护 儿童患者 

分 类 号：R725.9[医药卫生—儿科]