注射用兰索拉唑致血小板减少  

Thrombocytopenia induced by lansoprazole for injection

作　　者：郑雪梅[1] 温悦[1] 

机构地区：[1]第三军医大学第三附属医院药剂科,重庆400042

出　　处：《中国药物应用与监测》2013年第6期363-364,共2页Chinese Journal of Drug Application and Monitoring

摘　　要：1例68岁男性患者,因呃逆反酸静脉给予注射用兰索拉唑(30 mg,bid),用药第7天行食管癌切除术,术后查血小板计数72×109·L-1。在继续使用兰索拉唑的基础上,给予注射用哌拉西林钠他唑巴坦钠、注射用头孢匹胺抗感染,中/长链脂肪乳注射液营养支持,呋塞米注射液等对症治疗,3 d后血小板计数下降至27×109·L-1。在其他治疗方案不变的情况下,立即停用注射用兰索拉唑,给予注射用重组人白介素-11(Ⅰ)及血小板输入治疗后,血小板计数逐渐恢复至正常。此后再次使用注射用兰索拉唑(30 mg,bid),患者血小板计数又出现大幅下降趋势,遂立即停药。次日,在未使用升血小板药物的情况下,患者血小板计数逐渐回升。One 68-year-old male patient with hiccups and sour regurgitation was treated with lansoprazole for injection （30 mg, bid）. Esophageal carcinectomy was performed at the seventh day. Platelet count was 72 × 109·L-1 after operation. Then piperacillin sodium and tazobactam sodium, cefpiramide for anti-infection, medium and long chain fat emulsion injection for nutrition support and furosemide were given to the patient. Three days later, platelet count dropped to 27 × 109·L-1. Lansoprazole was stopped, the patient＇s platelet count recovered to normal range with the help of recombinant human interleukin-11 for injection and platelet transfusion. Lansoprazole was given to the patient once again and platelet count obviously dropped. So lansoprazole was stopped immediately and platelet count increased next day without using any other drugs. Thrombocytopenia induced by lansoprazole was considered.

关 键 词：兰索拉唑 血小板减少 药品不良反应 

分 类 号：R595.3[医药卫生—内科学]