痛风患者载脂蛋白C-Ⅲ启动子C-482T和T-455C的单核苷酸多态性与脂代谢紊乱  

The relationship between C-482T and T-455C single nucleotide polymorphism in ApoC-Ⅲ and high triglyceride of gout patients

作　　者：刁玉荃[1,2] 王颜刚[3] 

机构地区：[1]青岛大学医学院,山东省266021 [2]青岛市市立医院急诊科 [3]青岛大学医学院附属医院内分泌科

出　　处：《中华临床医师杂志（电子版）》2013年第19期48-50,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的通过研究痛风患者载脂蛋白C-Ⅲ(ApoC-Ⅲ)启动子的单核苷酸多态性与高甘油三酯(HTG)血症之间的关系,探讨该基因变异与痛风病程进展的关系。方法测定中国山东地区300例痛风患者及300例健康人群中的ApoC-Ⅲ启动子的两个位点C-482T和T-455C的基因型和等位基因频率,同时测定两组人群的血脂水平,并对其进行比较。结果痛风组较对照组TG水平增高,差异有统计学意义(t=6.75,P<0.01)。455位点的CC、CT和TT基因型在痛风组和对照组中分布频率分别为23.0%、24.0%、53.0%和30.3%、13.3%、56.3%,差异有统计学意义(χ2=12.47,P<0.01);455位点等位基因C的分布频率在痛风组和对照组中49.5%和58.5%,差异有显著性统计学意义(χ2=9.78,P<0.01);482位点的CC、CT和TT基因型在痛风组和对照组中分布频率分别为28.0%、23.0%、49.0%和16.0%、33.7%、50.3%,差异有显著性统计学意义(χ2=15.89,P<0.01);482位点等位基因T的分布频率在痛风组和对照组中47.5%和58.8%,差异有统计学意义(χ2=15.47,P<0.01)。结论 ApoC-Ⅲ启动子的455和482位点的基因多态性与痛风患者的HTG发病有关。Objective To study the relationship between single nucleotide polymorphism of promoter apolipoprotein C-III （ApoC-III） and high triglyceride （HTG） of the gout patients, to explore the relationship between the gene mutation and gout disease. Methods Two promoter loci C-482T and T-455C genotype in ApoC-III in 300 gout patients and 300 healthy control in Shandong province of China were determinated, blood lipid levels were also determined in the two groups, and then compared. Results The level of TG in gout group were higher than healthy control （t=6.75, P〈0.01）; there was significant difference between gout group and healthy control in loci 455, CC CT TT were 23.0%, 24.0%, 53.0% in gout group, and 30.3%, 13.3%, 56.3% in healthy control （Z2= 12.47, P〈0.01）. The frequency distribution of gene C in loci 455 were respectively 49.5% and 58.5% in gout group and healthy control （x2 = 15.89, P〈0.01）; there was significant difference between gout group and healthy control in loci 482, CC CT TT were 28.0%, 23.0%, 49.0% in gout group, and 16.0%, 33.7%, 50.3% in healthy control（x2= 15.89, P〈0.01）. The frequency distribution of gene C in loci 482 were respectively 47.5% and 58.8% in gout group and healthy control （x2=15.47, P〈0.01）. Conclusion There were relationship between gene promoter 455 and 482 polymorphism in ApoC-III and the pathogenesis of HTG in gout patients.

关 键 词：载脂蛋白CIII 痛风 高甘油三酯血症 单核苷酸多态性 

分 类 号：R589.7[医药卫生—内分泌]