PRDM在生殖细胞发育中的作用  

Role of PRDM in germ cell development

作　　者：韩海棠[1] 周波[1] 

机构地区：[1]中国农业大学生物学院,北京100193

出　　处：《生命的化学》2013年第6期653-656,共4页Chemistry of Life

基　　金：国家自然科学基金项目(31101045)

摘　　要：生殖细胞特化是发育和遗传的基础。原始生殖细胞(精子和卵子的前体细胞)的特化包括3个主要事件:体细胞程序的抑制、潜在全能性的获得、基因组范围内的表观遗传重编程。含PR域蛋白1(PR domain-containing 1,PRDM1)和PRDM14是生殖细胞系产生的关键转录调节因子。PRDM1主要抑制体细胞程序,而PRDM14主要调节潜在全能性的获得及表观遗传学重编程。此外,PRDM家族蛋白PRDM9在生殖细胞减数分裂中有重要作用。Germ cell specification is fundamental in development and heredity. Specification of primordial germ cell （PGC）, which is the founder cells of the oocytes and spermatozoa, includes three key events： the repression of somatic program, the re-acquisition of potential pluripotency, and the genome-wide epigenetic reprogramming. PR domain-containing 1 （PRDM1） and PRDM14 are critical transcriptional regulators that govern the birth of the germ cell lineage. PRDM 1 has a dominant role for the repression of somatic program. PRDM14, in contrast, regulates the re-acquisition of potential pluripotency and epigenetic reprogramming. Another member of PRDM protein, PRDM9, has shown to be essential for germ cells meiosis.

关 键 词：PRDM 生殖细胞 特化 

分 类 号：Q954.43[生物学—动物学]