药源性耳聋防治研究进展  

Advances in Prevention and Treatment of Drug-induced Deafness

作　　者：司继刚[1] 

机构地区：[1]山东省淄博市中心医院药学部,山东淄博255036

出　　处：《中国药物警戒》2013年第12期730-733,共4页Chinese Journal of Pharmacovigilance

摘　　要：为进一步了解耳毒性药物的种类和致聋机理,探讨预防和治疗耳聋的策略,对国内外近些年来报道的药源性耳聋相关文献进行整理、总结,药物的耳毒性与遗传、用药剂量、用药时间、给药途径、患者年龄和身体状况等有关。耳毒性药物涉及品种众多,造成的后果严重,应引起临床重视,加强临床合理用药,以预防为主,早发现,早治疗,减轻患者痛苦。In order to further understand the types of ototoxic drugs and the mechanism of deafness, and to explore the prevention and treatment strategies of drug-induced deafness, literatures about drug-induced deafness at home and abroad in recent years were collected, summarized and analyzed. The ototoxicity of drugs is related not only with hereditary, dose, length of time and administration route, but also with age and physical condition. The ototoxic drugs involve many kinds of chemicals and they will cause unimaginably serious consequence. More attention should be paid in clinical practice,clinical rational drug use should be strengthened. Prevention first and appropriate treatment as early as possible are the therapeutic strategies of the drug-induced deafness.

关 键 词：药源性耳聋 耳毒性 氨基糖苷类 合理用药 

分 类 号：R969.3[医药卫生—药理学]