耐甲氧西林金黄色葡萄球菌致下呼吸道医院感染危险因素分析  

Analysis of Risk Factors for Nosocomial Lower Respiratory Tract Infections Caused by Methicillin-resistant Staphylococcus aureus

作　　者：何晓锋[1] 曹晋桂[1] 张虎[1] 王健康[2] 吴镝[1] 刘芳[1] 

机构地区：[1]空军总医院感染控制科,北京100142 [2]空军总医院药学部

出　　处：《实用预防医学》2013年第12期1493-1494,共2页Practical Preventive Medicine

摘　　要：目的了解导致耐甲氧西林金黄色葡萄球菌(MRSA)引起的下呼吸道医院感染的危险因素。方法对180例金黄色葡萄球菌所致下呼吸道医院感染病例进行回顾性分析,采用病例对照研究和Logistic回归分析方法,筛选MRSA下呼吸道医院感染的独立危险因素。结果单因素分析提示年龄、性别、吸烟、住院天数和早期使用β-内酰胺类抗菌药物等可能是MRSA感染的危险因素,多因素Logistic回归分析确定痰培养阳性前的住院时间和使用β-内酰胺类抗菌药物是MRSA所致下呼吸道医院感染的独立危险因素。结论合理使用β-内酰胺类抗菌药物,严格掌握住院时间,对防止MRSA引起的下呼吸道医院感染非常重要。Objective To investigate the risk factors for nosocomial lower respiratory tract infections caused by methicillin -resistant Staphylococcus aureus （MRSA）.Methods One hundred and eighty cases of nosocomial lower respiratory tract infections caused by Staphylococcus aureus were analyzed retrospectively.The independent risk factors for the infections caused by MRSA were analyzed by using case-control study method and Logistic regression technique.Results Single factor analysis showed that age,sex,smoking,length of hospitalization and using β-lactam antimicrobial agents in the early period might be the independent risk factors for MRSA infection.Multi-factor Logistic regression analysis conclusively proved that the independent risk factors for lower respiratory tract nosocomial infections caused by MRSA were hospitalization days before sputum culture producing a positive result and use of β-lactam antimicrobial agents.Conclusions It is very important to prevent MRSA infection by rational application of β-lactam antimicrobial agents and strict limitation of hospitalization days.

关 键 词：耐药 金黄色葡萄球菌 危险因素 预防 治疗 

分 类 号：R378[医药卫生—病原生物学]