碘化钠促进的2-溴代苯并呋喃的氰化反应研究  

Study on the Sodium Iodide Promoted Cyanation of 2-Bromobenzofurans

作　　者：周丽[1] 周密[1] 王传虎[1] 

机构地区：[1]蚌埠学院,安徽蚌埠233030

出　　处：《廊坊师范学院学报（自然科学版）》2013年第6期42-44,共3页Journal of Langfang Normal University(Natural Science Edition)

基　　金：蚌埠学院院级自然科学项目(2013ZR09)

摘　　要：2-氰基苯并呋喃类化合物通常具有很强的生物活性,常用于药物分子和天然产物的构建。2-溴苯并呋喃类化合物在碘化钠做促进剂的条件下与氰化亚铜发生氰化反应,一步得到2位被氰基取代的呋喃衍生物。该方法实现了无过渡金属催化剂的溴代杂环化合物的氰化反应,有效减少了过渡金属催化剂对产品的污染。2-Cyanobenzofurans were widely utilized in the construction of pharmaceutical molecules and natural products for their high bioactivities. A series of 2-cyanobcnzofurans were obtained in high yields through the cyanation of 2-bromo- benzofurans under the conditions of sodium iodide as promoters and cuprous cyanide as cyanating reagents. This method has realized the cyanation of heterocyclic bromide under transition metal catalyst free conditions and avoided the contami- nating of products from transition metal catalyst successfully.

关 键 词：碘化钠 2-溴苯并呋喃 氰化 2-氰基苯并呋喃 

分 类 号：O626.11[理学—有机化学]