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机构地区:[1]武警后勤学院附属医院,天津300309 [2]武警后勤学院基础部,天津300309
出 处:《医疗卫生装备》2013年第12期1-3,共3页Chinese Medical Equipment Journal
基 金:武警医学院总部级科研基金(WKH2004-3);武警部队后勤部科研基金(WJHQ2010-15)
摘 要:目的:制备抗菌性能优良的创伤敷料,并对该敷料进行结构表征和抗菌性能评价。方法:首先通过离子交换法制备载银羟基磷灰石(Ag—HA),再利用柠檬酸将Ag—HA与纤维素复合制备Ag—HA抗菌敷料。通过XRD、SEM考察羟基磷灰石(HA)、Ag—HA的物相组成及形貌特征,采用平皿扩散法对Ag—HA敷料进行抗菌性能评价。结果:实验结果显示,Ag+进入HA晶格内部,所得功能成分Ag—HA的载银率为2.5%。Ag—HA颗粒均匀分布于敷料表面,呈圆球状,直径为0-4~0.5um。Ag—HA敷料对S.aureus和E.coli的抑菌带宽分别为2.0、1.0mm。结论:Ag—HA敷料具有很强的抗菌性能.可作为灾害救援和野外作业等特殊环境下的创伤包扎敷料。Objective To prepare an antibacterial wound Ag-HA dressing and study its structural characteristics and antibacte- rial properties. Methods Ag-HA was prepared by ion exchange method, and the Ag-HA dressing was manufactured by using citric acid as a cross-linking agent. The phase compositions and form feature of the of HA and Ag-HA were detected by XRD and SEM, and the antibacterial properties of Ag-HA dressing were tested by plate diffusion method. Rosults The silver content of Ag-HA was 2.5%, with Ag+ entering HA crystal. SEM showed that Ag-HA particles, which loaded on the Ag-HA dressing sur- face, were spherical with a diameter between 0.4 μm and 0.5μm. Antibacterial experiments showed that the antibacterial band- widths against S.aureus and E.coli were 2.0 mm and 1.0 mm respectively. Conclusion Ag-HA dressing has strong antibacterial properties, and can be used as the wound dressing in special circumstances such as disaster relief and field operation.
分 类 号:R318.08[医药卫生—生物医学工程]
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