载银羟基磷灰石抗菌敷料制备及其性能研究  被引量:1

Preparation of Ag-HA Dressing and Study on Its Antibacterial Properties

在线阅读下载全文

作  者:汪超[1] 刘玮[2] 郝鹤[2] 张力[2] 

机构地区:[1]武警后勤学院附属医院,天津300309 [2]武警后勤学院基础部,天津300309

出  处:《医疗卫生装备》2013年第12期1-3,共3页Chinese Medical Equipment Journal

基  金:武警医学院总部级科研基金(WKH2004-3);武警部队后勤部科研基金(WJHQ2010-15)

摘  要:目的:制备抗菌性能优良的创伤敷料,并对该敷料进行结构表征和抗菌性能评价。方法:首先通过离子交换法制备载银羟基磷灰石(Ag—HA),再利用柠檬酸将Ag—HA与纤维素复合制备Ag—HA抗菌敷料。通过XRD、SEM考察羟基磷灰石(HA)、Ag—HA的物相组成及形貌特征,采用平皿扩散法对Ag—HA敷料进行抗菌性能评价。结果:实验结果显示,Ag+进入HA晶格内部,所得功能成分Ag—HA的载银率为2.5%。Ag—HA颗粒均匀分布于敷料表面,呈圆球状,直径为0-4~0.5um。Ag—HA敷料对S.aureus和E.coli的抑菌带宽分别为2.0、1.0mm。结论:Ag—HA敷料具有很强的抗菌性能.可作为灾害救援和野外作业等特殊环境下的创伤包扎敷料。Objective To prepare an antibacterial wound Ag-HA dressing and study its structural characteristics and antibacte- rial properties. Methods Ag-HA was prepared by ion exchange method, and the Ag-HA dressing was manufactured by using citric acid as a cross-linking agent. The phase compositions and form feature of the of HA and Ag-HA were detected by XRD and SEM, and the antibacterial properties of Ag-HA dressing were tested by plate diffusion method. Rosults The silver content of Ag-HA was 2.5%, with Ag+ entering HA crystal. SEM showed that Ag-HA particles, which loaded on the Ag-HA dressing sur- face, were spherical with a diameter between 0.4 μm and 0.5μm. Antibacterial experiments showed that the antibacterial band- widths against S.aureus and E.coli were 2.0 mm and 1.0 mm respectively. Conclusion Ag-HA dressing has strong antibacterial properties, and can be used as the wound dressing in special circumstances such as disaster relief and field operation.

关 键 词:Ag—HA抗菌敷料 制备 抗菌性能 

分 类 号:R318.08[医药卫生—生物医学工程]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象