单方和复方给药后格列美脲在Beagle犬体内药物动力学的比较  

Pharmacokinetics comparison of glimepiride tablet and compound metformin and glimepiride tablet in Beagle dogs

作　　者：廖春[1] 邸欣[1] 王鑫[1] 张丽[1] 刘有平[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2013年第12期927-932,共6页Journal of Shenyang Pharmaceutical University

摘　　要：目的比较复方二甲双胍格列美脲片与单方格列美脲片中的格列美脲在Beagle犬体内的药物动力学差异。方法6只Beagle随机分为2组,犬单剂量口服单方格列美脲片和复方二甲双胍格列美脲片后,利用LC-MS/MS法分析血浆中格列美脲的浓度。采用DAS 2.1.1软件对主要药物动力学参数进行计算,并用SPSS 16.0软件对其进行配对t检验和非参数检验。结果Beagle犬单剂量口服单方格列美脲片与复方二甲双胍格列美脲片的主要药物动力学参数如下:ρmax分别为(1 722.9±237.8)和(1 860.6±315.2)μg·L-1,tmax分别为(3.3±0.3)和(3.2±0.3)h,AUC0→t分别为(12 456.9±31 93.6)和(12 048.1±3 577.8)μg·h·L-1,AUC0→∞分别为(12 578.4±3 167.2)和(12 330.4±3 756.8)μg·h·L-1。经统计学检验,各药物动力学参数间无显著性差异(P>0.05)。结论复方二甲双胍格列美脲片中的格列美脲在Beagle犬体内的药物动力学过程与单方相比无显著差异。Objective To compare the pharmacokinetic differences between glimepiride tablet and compound glimepiride tablet in Beagle dogs. Methods Six Beagle dogs were randomly divided into 2 groups, and orally administrated amaryl tablet or compound glimepiride tablet respectively. The concentrations of glimepiride in Beagle plasma were determined by LC-MS/MS. The pharmacokinetic parameters were calculated by DAS 2. 1.1 software, and the statistical differences were evaluated with SPSS 16.0 software by independent sam- ple t-test or nonparametric test. Results The main pharmacokinetic parameters of glimepiride tablet and com- pound glimepiride tablet were as follows ＂Pinax were （ 1 722. 9 ＋ 358.0 ） and （ 1 860. 6 ＋ 618.4 ） p^g. L-~; tm^x were（3.417 ＋ 0. 529） and （ 3.0 _＋ 0. 5 ） h; AUC0t were （ 12 641.1 ~ 4 324. 7 ） and （ 12 087.5 ~ 7 106. 4 ） ixg.h-L-~ ;AUC0 were（ 12 909.9 ~4 420. 9） and（ 12 538.0 ~7 338.0） Ixg＇h＇L -~ ,respectively. The sta- tistical results show that there were no significant differences in the pharmacokinetic parameters （ P 〉 0.05 ）. Conclusions The pharmacokinefic results show that there were no significant pharmacokinetic difference of glimepiride in Beagle dogs between glimepiride tablet and compound metformin and glimepiride tablet.

关 键 词：复方二甲双胍格列美脲片 格列美脲 液相色谱-串联质谱 药物动力学 

分 类 号：R917[医药卫生—药物分析学]