盐酸左旋西替利嗪咀嚼片的制备与含量测定  

Preparation and Content Determination of levocetirizine chewable tablets

作　　者：林朝晖 

机构地区：[1]福建生物工程职业技术学院,福建福州350002

出　　处：《中国药业》2013年第24期45-46,共2页China Pharmaceuticals

摘　　要：目的研制盐酸左旋西替利嗪咀嚼片，并确定其含量检测方法。方法以粉末直接压片法制备工艺对盐酸左旋西替利嗪咀嚼片处方进行制备；采用可见一紫外分光光度法对其进行含量测定，并对方法进行考察。结果制备的盐酸左旋西替利嗪咀嚼片12＇感良好，符合咀嚼片要求；盐酸左旋西替利嗪在2．0～40．0Ixg／mL质量浓度范围内线性良好（r=0．9997），平均回收率为98．99％，RSD=0．29％。结论制得的盐酸西替利嗪咀嚼片处方合理，制备工艺适宜规模化生产；可见一紫外分光光度法检测本品含量简便、快速、准确，可用于盐酸左旋西替利嗪咀嚼片的含量测定相下的质量控制。Objective To prepare the levocetirizine chewable tablets and determine the detection methods of the content. Method The levocetirizine hydrochloride chewable tablets was prepared by the prescription using the direct compression process in powder;The UV- visible spectrophotometry was performed for the content detection and the method was validated. Results The levocetirizine chewable tablets taste good in accordance with the chewable requirements;The levocetirizine was linear in the range of 2.0-40.0 p,g/mL （r = 0. 999 7）and the average recovery was 98.99%, RSD = 0.29%. Conclusions The resulting prescription of the levocetirizine chew- able was reasonable,the preparation process was suitable for industrialized production;The UV- visible spectrophotometry to determine the content of this product is simple,fast, accurate and can be used for the levocetirizine hydrochloride chewable content determination under control quality phase.

关 键 词：盐酸左旋西替利嗪 咀嚼片 含量测定 

分 类 号：R944.4[医药卫生—药剂学] R976[医药卫生—药学]