系统性红斑狼疮并发隐球菌性脑膜炎  

Cryptococcus meningitis in a patient with systemic lupus erythematosus:a case report

作　　者：陈娟[1] 邓丹琪[1] 张佩莲[1] 周晓鸿[1] 毕云凤[1] 陈超超[1] 

机构地区：[1]昆明医科大学第二附属医院皮肤性病/风湿免疫科,云南昆明650101

出　　处：《临床皮肤科杂志》2014年第1期19-20,共2页Journal of Clinical Dermatology

摘　　要：报告1例系统性红斑狼疮(SLE)并发隐球菌性脑膜炎。患者女,21岁。妊娠晚期确诊为SLE,经大剂量甲泼尼龙联合环磷酰胺治疗后出现发热、头痛,血培养及脑脊液培养检出隐球菌,诊断为罗伦隐球菌性脑膜炎。给予两性霉素B、氟康唑、氟胞嘧啶联合抗真菌治疗后症状好转,脑脊液培养转阴。病程中以小剂量泼尼松维持SLE治疗。A case of Cryptococcus meningitis in a patient with systemic lupus erythematosus （SLEI~ is reported. A 21-year- old female was diagnosed with SLE when she was in the third trimester of pregnancy. She had fever and headache following the treatment with high dose methyl-prednisolone and eyclophosphamide. Blood and cerebrospinal fluid （CSF） cultured grew Cryptococcus. A diagnosis of Cryptococcus meningitis was made. The symptoms were improved and CSF culture became nega- tive after the treatment with amphotericin B liposome, fluconazole, flucytosine, as well as anti-funga] agents. During the treat- ment, low dose prednisone was also given for maintenance therapy of SLE.

关 键 词：红斑狼疮 系统性 脑膜炎 隐球菌性 

分 类 号：R756.6[医药卫生—皮肤病学与性病学] R512.3[医药卫生—临床医学]