羟乙基淀粉200/0.5氯化钠注射液置换度测定方法的改进  

Improved Method for Substitution Determination of Hydroxyethyl Starch 200/0.5 and Sodium Chloride Injections

作　　者：王棘[1] 潘雪妍[1] 

机构地区：[1]辽宁省食品药品检验所,沈阳110023

出　　处：《中国药师》2013年第12期1836-1838,共3页China Pharmacist

摘　　要：目的:改进羟乙基淀粉200/0.5氯化钠注射液置换度的测定方法。方法:使用Agilent DB-5毛细管色谱柱(30 m×0.32 mm×0.25μm),检测器:氢火焰离子化检测器,柱温:程序升温,进样口250℃,检测器280℃,载气:N_2,流速.2.0 ml·min^1,分流比:1:30。结果:碘乙烷浓度在9.490 4~47.452 0 g·L^(-1)范围内线性关系良好,r=0.999 7,平均回收率为101.8%(RSD=1.5%,n=9)。结论:本方法可用于羟乙基淀粉200/0.5氯化钠注射液置换度快速分析。Objective：To improve the method for the substitution determination of hydroxyethyl starch 200/0.5 and sodium chlordde injections.Method：An Agilent DB-5 capillary column（30 mm×0.32 mm,0.25μm） was adopted using hydrogen flame ionization detector with temperature programming.The injection temperature was 250℃ and the FID detector temperature was 280℃.The flow rate of nitrogen was 2.0 ml？min-1 and the split ratio was 1：30.Result：A good linearity was shown within the range of 9.490 447.452 0g？L-1 for ethyliodide（r = 0.9997）.The averuge recovery was 101.8%（RSD =1.5%,n.= 9）.Conclusion：The method can be used in the fast analysis on the substitution of hydroxyethyl starch 200/0.5 and sodium chloride injections.

关 键 词：气相色谱法 羟乙基淀粉200 0 5氯化钠注射液 置换度 

分 类 号：R927.2[医药卫生—药学]