A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2  

作　　者：Ye Li Kun-Lai Sun Yi Wang Peng Fu Pei-Pei Liu Chen Wang Wei-Ming Zhu 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China

出　　处：《Chinese Chemical Letters》2013年第12期1049-1052,共4页中国化学快报（英文版）

基　　金：financially supported by NSFC (No. 21172204)&NSFS (No. ZR2009CQ014);863 Program of China (Nos. 2013AA092901, 2012AA092104 and 2011AA09070106);973 Program of China (No. 2010CB833804);Scientifc Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China (No. [2010]1174)

摘　　要：A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.

关 键 词：Cristatumin E Pyrrolidinoindoline diketopiperazine dimer Eurotium herbariorum Algal fungus Cytotoxicity Enteromorpha prolifera Marine algae 

分 类 号：O631.3[理学—高分子化学]