Gold-catalyzed oxazoles synthesis and their relevant antiproliferative activities  

作　　者：Chao Wu Zhi-Wu Liang Ying-Ying Xu Wei-Min He Jian-Nan Xiang 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University

出　　处：《Chinese Chemical Letters》2013年第12期1064-1066,共3页中国化学快报（英文版）

基　　金：supported by NSFC (No. 21276068);Department of Science and Technology Foundation of Hunan Province (No. 2010SK2001);Hunan Natural Science Foundation (No. 11JJ5008)

摘　　要：Nine 5-aryl-2-methyloxazole derivatives were synthesized via gold-catalyzed alkyne oxidation. All of the compounds have been screened for their antiproliferative activities against MCF-7 cell （human breast carcinoma）, A549 cell （human lung carcinoma） and Hela cell （human cervical carcinoma） lines in vitro. The results revealed that compounds 1b, 1c and 1d exhibited strong inhibitory activities against the MCF-7 cell lines （with ICso values of 4.6, 9.7 and 2.2 μmol/L, respectively）.Nine 5-aryl-2-methyloxazole derivatives were synthesized via gold-catalyzed alkyne oxidation. All of the compounds have been screened for their antiproliferative activities against MCF-7 cell （human breast carcinoma）, A549 cell （human lung carcinoma） and Hela cell （human cervical carcinoma） lines in vitro. The results revealed that compounds 1b, 1c and 1d exhibited strong inhibitory activities against the MCF-7 cell lines （with ICso values of 4.6, 9.7 and 2.2 μmol/L, respectively）.

关 键 词：Oxazole Synthesis Gold-catalyzed Biological activity 

分 类 号：O621.3[理学—有机化学]