Tetracyclic triterpenoids isolated from semi-mangrove plant Hibiscus tiliaceus  

作　　者：Can-Ling Cheng Zhong-Zhao Wang Ping-Lin Li Xing-Wang Zhang Rong-Cui Wu Hong-Yan Zhu Xu-Li Tang Guo-Qiang Li 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China [2]College of Chemistry and Chemical Engineering,Ocean University of China

出　　处：《Chinese Chemical Letters》2013年第12期1080-1082,共3页中国化学快报（英文版）

基　　金：supported by the Key International Cooperation Project of CMST (No. 2008DFA31040);the Special Funds for Young Teachers of Ocean University of China (No.841113070)

摘　　要：A continuing phytochemical study on the semi-mangrove plant Hibiscus tiliaceus yielded two new tetracyclic triterpenoids （3β,24S）-19（10→9）-abeo-8α,9β,10α-eupha-5,25（26）-dien-3,24-diol （tiliacol A, 1 ）, and （3β,23Z）-19（10→9）-abeo-8α,9β,10α-tircalla-5,23-dien-3,25-diol （tiliacol B, 3）, together with one known analog （2）. Their structures were elucidated on the basis of extensive spectral analyses （MS, IR, 1D NMR and 2D NMR） and comparison with literature compounds. Compound 2 showed potent cytotoxicity against both P388 and HeLa cells with ICon values of 11.2 μmol/L and 11.5 μmol/L, resoectively.A continuing phytochemical study on the semi-mangrove plant Hibiscus tiliaceus yielded two new tetracyclic triterpenoids （3β,24S）-19（10→9）-abeo-8α,9β,10α-eupha-5,25（26）-dien-3,24-diol （tiliacol A, 1 ）, and （3β,23Z）-19（10→9）-abeo-8α,9β,10α-tircalla-5,23-dien-3,25-diol （tiliacol B, 3）, together with one known analog （2）. Their structures were elucidated on the basis of extensive spectral analyses （MS, IR, 1D NMR and 2D NMR） and comparison with literature compounds. Compound 2 showed potent cytotoxicity against both P388 and HeLa cells with ICon values of 11.2 μmol/L and 11.5 μmol/L, resoectively.

关 键 词：Semi-mangrove Hibiscus tiliaceus （Malvaceae） Triterpenoid Cytotoxicity 

分 类 号：R284[医药卫生—中药学]